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- W2314486578 endingPage "7064" @default.
- W2314486578 startingPage "7054" @default.
- W2314486578 abstract "Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up approach for re-engineering the molecular landscape of cell surfaces with spatially continuous and molecularly uniform ultrathin films. However, fabricating PEMs on viable cells has proven challenging owing to the high cytotoxicity of polycations. Here, we report the rational engineering of a new class of PEMs with modular biological functionality and tunable physicochemical properties which have been engineered to abrogate cytotoxicity. Specifically, we have discovered a subset of cationic copolymers that undergoes a conformational change, which mitigates membrane disruption and facilitates the deposition of PEMs on cell surfaces that are tailorable in composition, reactivity, thickness, and mechanical properties. Furthermore, we demonstrate the first successful in vivo application of PEM-engineered cells, which maintained viability and function upon transplantation and were used as carriers for in vivo delivery of PEMs containing biomolecular payloads. This new class of polymeric film and the design strategies developed herein establish an enabling technology for cell transplantation and other therapies based on engineered cells." @default.
- W2314486578 created "2016-06-24" @default.
- W2314486578 creator A5000841694 @default.
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- W2314486578 creator A5046973434 @default.
- W2314486578 creator A5070809986 @default.
- W2314486578 creator A5086039900 @default.
- W2314486578 date "2011-04-14" @default.
- W2314486578 modified "2023-10-02" @default.
- W2314486578 title "Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films" @default.
- W2314486578 cites W1503426215 @default.
- W2314486578 cites W1965825251 @default.
- W2314486578 cites W1969492390 @default.
- W2314486578 cites W1970625396 @default.
- W2314486578 cites W1972706590 @default.
- W2314486578 cites W1972801619 @default.
- W2314486578 cites W1975542874 @default.
- W2314486578 cites W1977878598 @default.
- W2314486578 cites W1980285981 @default.
- W2314486578 cites W1980651080 @default.
- W2314486578 cites W1981659539 @default.
- W2314486578 cites W1982029216 @default.
- W2314486578 cites W1982271893 @default.
- W2314486578 cites W1982769493 @default.
- W2314486578 cites W1983516733 @default.
- W2314486578 cites W1985017185 @default.
- W2314486578 cites W1986794115 @default.
- W2314486578 cites W1988901523 @default.
- W2314486578 cites W1988947046 @default.
- W2314486578 cites W1993343583 @default.
- W2314486578 cites W1993352731 @default.
- W2314486578 cites W1994826584 @default.
- W2314486578 cites W1996386974 @default.
- W2314486578 cites W1997099073 @default.
- W2314486578 cites W1999666701 @default.
- W2314486578 cites W2000082963 @default.
- W2314486578 cites W2002975889 @default.
- W2314486578 cites W2005264423 @default.
- W2314486578 cites W2005948537 @default.
- W2314486578 cites W2006919788 @default.
- W2314486578 cites W2010168107 @default.
- W2314486578 cites W2010929082 @default.
- W2314486578 cites W2012317052 @default.
- W2314486578 cites W2012320162 @default.
- W2314486578 cites W2013333439 @default.
- W2314486578 cites W2015623407 @default.
- W2314486578 cites W2022282748 @default.
- W2314486578 cites W2023862597 @default.
- W2314486578 cites W2026801512 @default.
- W2314486578 cites W2026932365 @default.
- W2314486578 cites W2028277897 @default.
- W2314486578 cites W2029702180 @default.
- W2314486578 cites W2029851331 @default.
- W2314486578 cites W2030635914 @default.
- W2314486578 cites W2031608074 @default.
- W2314486578 cites W2035500216 @default.
- W2314486578 cites W2040077874 @default.
- W2314486578 cites W2040682389 @default.
- W2314486578 cites W2040939976 @default.
- W2314486578 cites W2042407360 @default.
- W2314486578 cites W2043934961 @default.
- W2314486578 cites W2044441655 @default.
- W2314486578 cites W2045112474 @default.
- W2314486578 cites W2045691265 @default.
- W2314486578 cites W2045856259 @default.
- W2314486578 cites W2046058245 @default.
- W2314486578 cites W2047106847 @default.
- W2314486578 cites W2050572274 @default.
- W2314486578 cites W2051584593 @default.
- W2314486578 cites W2054635074 @default.
- W2314486578 cites W2054715716 @default.
- W2314486578 cites W2057190776 @default.
- W2314486578 cites W2057517167 @default.
- W2314486578 cites W2058310958 @default.
- W2314486578 cites W2059099393 @default.
- W2314486578 cites W2062490445 @default.
- W2314486578 cites W2066808970 @default.
- W2314486578 cites W2068272967 @default.
- W2314486578 cites W2072457858 @default.
- W2314486578 cites W2074350835 @default.
- W2314486578 cites W2076053527 @default.
- W2314486578 cites W2081270428 @default.
- W2314486578 cites W2085123622 @default.
- W2314486578 cites W2086069830 @default.
- W2314486578 cites W2086432921 @default.
- W2314486578 cites W2088115344 @default.
- W2314486578 cites W2088748449 @default.
- W2314486578 cites W2090380610 @default.
- W2314486578 cites W2091152671 @default.
- W2314486578 cites W2091163090 @default.