FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314498082> ?p ?o ?g. }

• W2314498082 endingPage "846" @default.
• W2314498082 startingPage "837" @default.
• W2314498082 abstract "Trimethyllysine 72 (Tml72) of yeast iso-1-cytochrome c lies across the surface of the heme crevice loop (Ω-loop D, residues 70–85) like a brace. Lys72 is oriented similarly in horse cytochrome c (Cytc). To determine whether this residue affects the dynamics of opening the heme crevice loop, we have studied the effect of a Tml72 to Ala substitution on the formation of the His79–heme alkaline conformer near neutral pH using a variant of iso-1-Cytc including K72A and K79H mutations. Guanidine hydrochloride denaturation shows that the Tml72 to Ala substitution within error does not affect the global stability of the protein. The effect of the Tml72 to Ala substitution on the thermodynamics of the His79–heme alkaline transition is also small. However, pH-jump kinetic studies of the His79–heme alkaline transition show that both the forward and backward rates of conformational change are increased by the Tml72 to Ala substitution. The barrier for opening the heme crevice is reduced by 0.5 kcal/mol and for closing the heme crevice by 0.3 kcal/mol. The ability of Tml72 to modulate the heme crevice dynamics may indicate a crucial role in regulating function, such as in the peroxidase activity seen in the early stages of apoptosis." @default.
• W2314498082 created "2016-06-24" @default.
• W2314498082 creator A5024686305 @default.
• W2314498082 creator A5055893342 @default.
• W2314498082 creator A5074549149 @default.
• W2314498082 date "2013-01-23" @default.
• W2314498082 modified "2023-10-06" @default.
• W2314498082 title "Mutation of Trimethyllysine 72 to Alanine Enhances His79–Heme-Mediated Dynamics of Iso-1-cytochrome <i>c</i>" @default.
• W2314498082 cites W1508064959 @default.
• W2314498082 cites W1523220226 @default.
• W2314498082 cites W1548084462 @default.
• W2314498082 cites W1633538413 @default.
• W2314498082 cites W1971874990 @default.
• W2314498082 cites W1973664438 @default.
• W2314498082 cites W1973948986 @default.
• W2314498082 cites W1975667451 @default.
• W2314498082 cites W1983276480 @default.
• W2314498082 cites W1983936961 @default.
• W2314498082 cites W1984055082 @default.
• W2314498082 cites W1985887161 @default.
• W2314498082 cites W1989082315 @default.
• W2314498082 cites W1993115198 @default.
• W2314498082 cites W1994088455 @default.
• W2314498082 cites W1996796347 @default.
• W2314498082 cites W1997535248 @default.
• W2314498082 cites W1997787755 @default.
• W2314498082 cites W1999724237 @default.
• W2314498082 cites W2005441809 @default.
• W2314498082 cites W2006769536 @default.
• W2314498082 cites W2015927778 @default.
• W2314498082 cites W2016185335 @default.
• W2314498082 cites W2016660369 @default.
• W2314498082 cites W2017076970 @default.
• W2314498082 cites W2025587541 @default.
• W2314498082 cites W2034538323 @default.
• W2314498082 cites W2037148211 @default.
• W2314498082 cites W2040360153 @default.
• W2314498082 cites W2043066236 @default.
• W2314498082 cites W2043613140 @default.
• W2314498082 cites W2045777307 @default.
• W2314498082 cites W2046002103 @default.
• W2314498082 cites W2046127532 @default.
• W2314498082 cites W2048822589 @default.
• W2314498082 cites W2048829910 @default.
• W2314498082 cites W2049436067 @default.
• W2314498082 cites W2062897750 @default.
• W2314498082 cites W2068841105 @default.
• W2314498082 cites W2072441592 @default.
• W2314498082 cites W2074444981 @default.
• W2314498082 cites W2074864002 @default.
• W2314498082 cites W2076598445 @default.
• W2314498082 cites W2079125529 @default.
• W2314498082 cites W2081736815 @default.
• W2314498082 cites W2083492588 @default.
• W2314498082 cites W2086142700 @default.
• W2314498082 cites W2091387166 @default.
• W2314498082 cites W2105732409 @default.
• W2314498082 cites W2117747873 @default.
• W2314498082 cites W2127362915 @default.
• W2314498082 cites W2134248388 @default.
• W2314498082 cites W2160903751 @default.
• W2314498082 cites W2166473439 @default.
• W2314498082 cites W2170070595 @default.
• W2314498082 cites W2170485699 @default.
• W2314498082 cites W2224792910 @default.
• W2314498082 cites W2313539474 @default.
• W2314498082 cites W2326260238 @default.
• W2314498082 cites W2337865873 @default.
• W2314498082 cites W4246448952 @default.
• W2314498082 doi "https://doi.org/10.1021/bi301599g" @default.
• W2314498082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23311346" @default.
• W2314498082 hasPublicationYear "2013" @default.
• W2314498082 type Work @default.
• W2314498082 sameAs 2314498082 @default.
• W2314498082 citedByCount "26" @default.
• W2314498082 countsByYear W23144980822013 @default.
• W2314498082 countsByYear W23144980822014 @default.
• W2314498082 countsByYear W23144980822015 @default.
• W2314498082 countsByYear W23144980822016 @default.
• W2314498082 countsByYear W23144980822017 @default.
• W2314498082 countsByYear W23144980822018 @default.
• W2314498082 countsByYear W23144980822019 @default.
• W2314498082 countsByYear W23144980822020 @default.
• W2314498082 countsByYear W23144980822021 @default.
• W2314498082 countsByYear W23144980822022 @default.
• W2314498082 crossrefType "journal-article" @default.
• W2314498082 hasAuthorship W2314498082A5024686305 @default.
• W2314498082 hasAuthorship W2314498082A5055893342 @default.
• W2314498082 hasAuthorship W2314498082A5074549149 @default.
• W2314498082 hasConcept C121332964 @default.
• W2314498082 hasConcept C12554922 @default.
• W2314498082 hasConcept C13965031 @default.
• W2314498082 hasConcept C148898269 @default.
• W2314498082 hasConcept C181199279 @default.
• W2314498082 hasConcept C185592680 @default.
• W2314498082 hasConcept C2776217839 @default.
• W2314498082 hasConcept C2776923230 @default.
• W2314498082 hasConcept C2779463914 @default.

• next