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• W2314513581 abstract "Human immunodeficiency virus (HIV) is associated with immune system activation and chronic inflammation. This study aimed to evaluate the effect of HIV infection on Albumin and Globulin fractions as a possible marker of inflammation in HIV infected subjects. This is a case controlled study involving one hundred (100) HIV sero-positive subjects made up of male and female aged 20-50years which consist of 50 sero-positive subjects on antiretroviral therapy (ART) for a minimum of 6 months and 50 sero-positive subjects not on ART yet all of which attend HIV clinic at Nnamdi Azikiwe University University Teaching Hospital (NAUTH), and 50 apparently healthy, age sex matched HIV sero-negative as control subjects. CD4 + T- cell count was estimated by Cyflow SLGreen. Alpha1microglobulin (α1M) and Beta2 microglobulin (β2M) were estimated by enzyme linked immunosorbent assay (ELISA). Albumin and total protein were estimated by colometric method, while globulin and albumin/globulin ratio were determined by calculation. The data obtained were subjected to statistical analysis using SPSS software application (version 21.0) and the results expressed as mean ± standard deviation. The serum levels of both αIM and β2M in ART group (29.5±18.22mg/l and 10.84±5.33µg/ml) and Non-ART (32.2±41.6mg/l and 15.45±10.8 µg/ml) were significantly higher compared to the control group (8.0±1.78mg/l and 6.89±2.31 µg/ml) (p<0.05). There was a significant difference (p<0.05) in albumin level in the ART group (39.0±7.43g/l) compared to Non-ART group (35.58±7.62g/l). Furthermore, Albumin was lowest in the Non-ART group (35.58±7.62g/l) and highest in the control (40.4±4.67g/l) while total protein was lowest in the control group (66.38±6.89g/l) and highest in the Non-ART group (82.34±13.63g/l) and when compared between the groups was statistically significant (p<0.05). Globulin was highest in the Non-ART group (46.80±12.60g/l) and lowest in the control group (25.90±3.10g/l), Albumin/globulin ratio was lowest in the Non-ART group (0.70±0.30) and highest in the control group (1.50±0.20) and when compared between the groups was statistically significant (p<0.05). Positive association was observed between α1M (r=0.303 p = 0.033) and Albumin (r = 0.333, p = 0.018) with CD4 + T cell in Non-ART group. In conclusion, the significant changes in the biochemical parameters measured suggest a redistribution in Albumin and globulin fractions in ART and Non-ART group especially the lowest Albumin/globulin ratio observed in the non-ART subjects indicate an active disease progression as against a regressive disease state in ART subjects. Hence, A/G ratio can be used as a prognostic marker for HIV infection." @default.
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• W2314513581 date "2015-01-01" @default.
• W2314513581 modified "2023-09-23" @default.
• W2314513581 title "Modulation of α1 and β2 Microglobulins, and Albumin-Globulin Ratio in HIV Sero-Positive Subjects on Antiretroviral Drugs at Nnewi, Nigeria - A Case Controlled Study" @default.
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