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• W2314521350 endingPage "1135" @default.
• W2314521350 startingPage "1129" @default.
• W2314521350 abstract "The preparation of biocompatible nanocarriers that have potential applications in the cosmetic and health industries is highly desired. The self-assembly of amphiphilic block copolymers displaying biosourced polysaccharides at the surface is one of the most promising approaches. In the continuity of our works related to the preparation of hybrid amphiphilic oligosaccharide-based block copolymers, we present here the design of a new generation of self-assembled nanoparticles composed entirely of oligosaccharide-based amphiphilic block co-oligomers (BCO). These systems are defined by a covalent linkage of the two saccharidic blocks through their reducing end units, resulting in a sweet head-to-head connection. As an example, we have prepared and studied a BCO in which the hydrophilic part is composed of a free maltoheptaosyl derivative clicked to a hydrophobic part composed of a peracetylated maltoheptaosyl derivative. This amphiphilic BCO self-assembles to form spherical micelles in water with an average diameter of 30 nm. The efficient enzymatic hydrolysis of the maltoheptaose that constitutes the shell of the micelles was followed by light scattering and colorimetric methods." @default.
• W2314521350 created "2016-06-24" @default.
• W2314521350 creator A5006705850 @default.
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• W2314521350 creator A5084785828 @default.
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• W2314521350 date "2012-03-23" @default.
• W2314521350 modified "2023-10-16" @default.
• W2314521350 title "Sweet Block Copolymer Nanoparticles: Preparation and Self-Assembly of Fully Oligosaccharide-Based Amphiphile" @default.
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• W2314521350 doi "https://doi.org/10.1021/bm3000138" @default.
• W2314521350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22397388" @default.
• W2314521350 hasPublicationYear "2012" @default.
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