FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314559944> ?p ?o ?g. }

• W2314559944 endingPage "381" @default.
• W2314559944 startingPage "376" @default.
• W2314559944 abstract "Angiogenesis is essential for growth and metastasis of solid tumors and probably also for hematological malignancies. Angiogenic inhibitors, like endostatin (ES) and PI-88, retard cancer growth. We tested these in mice with juvenile myelomonocytic leukemia (JMML), and in rats with acute myeloid leukemia (BNML). Eight weeks after transplantation and with a continuous drug treatment for the last 4 weeks, the leukemic cell mass decreased from almost 90% of all bone marrow cells to about 15 and 45% with ES, to about 35 and 55% with PI-88, and to about 10 and 25% with ES + PI-88 in the leukemic mice and rats, respectively. The numbers of normal human bone marrow cells transplanted into mice were unchanged by the treatments. The microvessel density in leukemic animals given ES or PI-88 was 10-50% of that in untreated animals. Notably, simultaneous treatment with ES and PI-88 led to a reduction of about 95% in JMML mice and 85% in BNML rats. In vitro proliferation of either JMML or BNML cells was not significantly altered by either drug, demonstrating the selectivity of ES and PI-88 as angiogenic inhibitors. In conclusion, anti-angiogenic therapy may be a valuable adjunct to conventional treatment of leukemia." @default.
• W2314559944 created "2016-06-24" @default.
• W2314559944 creator A5063368563 @default.
• W2314559944 creator A5081783236 @default.
• W2314559944 creator A5086410043 @default.
• W2314559944 date "2002-03-01" @default.
• W2314559944 modified "2023-10-18" @default.
• W2314559944 title "Inhibitors of angiogenesis selectively reduce the malignant cell load in rodent models of human myeloid leukemias" @default.
• W2314559944 cites W1566059459 @default.
• W2314559944 cites W1567732942 @default.
• W2314559944 cites W1569373357 @default.
• W2314559944 cites W1573363574 @default.
• W2314559944 cites W182858095 @default.
• W2314559944 cites W1985804036 @default.
• W2314559944 cites W2010261137 @default.
• W2314559944 cites W2013538303 @default.
• W2314559944 cites W2015809080 @default.
• W2314559944 cites W2036308986 @default.
• W2314559944 cites W2042999054 @default.
• W2314559944 cites W2055715830 @default.
• W2314559944 cites W2069492277 @default.
• W2314559944 cites W2085396553 @default.
• W2314559944 cites W2131798870 @default.
• W2314559944 cites W2133286763 @default.
• W2314559944 cites W2167647586 @default.
• W2314559944 cites W2325372479 @default.
• W2314559944 cites W339969875 @default.
• W2314559944 cites W35069712 @default.
• W2314559944 cites W4240674955 @default.
• W2314559944 cites W4246026822 @default.
• W2314559944 cites W4381937407 @default.
• W2314559944 doi "https://doi.org/10.1038/sj.leu.2402376" @default.
• W2314559944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11896541" @default.
• W2314559944 hasPublicationYear "2002" @default.
• W2314559944 type Work @default.
• W2314559944 sameAs 2314559944 @default.
• W2314559944 citedByCount "40" @default.
• W2314559944 countsByYear W23145599442012 @default.
• W2314559944 countsByYear W23145599442014 @default.
• W2314559944 countsByYear W23145599442016 @default.
• W2314559944 countsByYear W23145599442017 @default.
• W2314559944 countsByYear W23145599442018 @default.
• W2314559944 countsByYear W23145599442019 @default.
• W2314559944 countsByYear W23145599442020 @default.
• W2314559944 countsByYear W23145599442021 @default.
• W2314559944 countsByYear W23145599442022 @default.
• W2314559944 crossrefType "journal-article" @default.
• W2314559944 hasAuthorship W2314559944A5063368563 @default.
• W2314559944 hasAuthorship W2314559944A5081783236 @default.
• W2314559944 hasAuthorship W2314559944A5086410043 @default.
• W2314559944 hasBestOaLocation W23145599441 @default.
• W2314559944 hasConcept C109159458 @default.
• W2314559944 hasConcept C126322002 @default.
• W2314559944 hasConcept C203014093 @default.
• W2314559944 hasConcept C2778271429 @default.
• W2314559944 hasConcept C2778461978 @default.
• W2314559944 hasConcept C2778729363 @default.
• W2314559944 hasConcept C2779157977 @default.
• W2314559944 hasConcept C2779282312 @default.
• W2314559944 hasConcept C2780007613 @default.
• W2314559944 hasConcept C2780394083 @default.
• W2314559944 hasConcept C28328180 @default.
• W2314559944 hasConcept C2911091166 @default.
• W2314559944 hasConcept C502942594 @default.
• W2314559944 hasConcept C54355233 @default.
• W2314559944 hasConcept C71924100 @default.
• W2314559944 hasConcept C75920679 @default.
• W2314559944 hasConcept C86803240 @default.
• W2314559944 hasConceptScore W2314559944C109159458 @default.
• W2314559944 hasConceptScore W2314559944C126322002 @default.
• W2314559944 hasConceptScore W2314559944C203014093 @default.
• W2314559944 hasConceptScore W2314559944C2778271429 @default.
• W2314559944 hasConceptScore W2314559944C2778461978 @default.
• W2314559944 hasConceptScore W2314559944C2778729363 @default.
• W2314559944 hasConceptScore W2314559944C2779157977 @default.
• W2314559944 hasConceptScore W2314559944C2779282312 @default.
• W2314559944 hasConceptScore W2314559944C2780007613 @default.
• W2314559944 hasConceptScore W2314559944C2780394083 @default.
• W2314559944 hasConceptScore W2314559944C28328180 @default.
• W2314559944 hasConceptScore W2314559944C2911091166 @default.
• W2314559944 hasConceptScore W2314559944C502942594 @default.
• W2314559944 hasConceptScore W2314559944C54355233 @default.
• W2314559944 hasConceptScore W2314559944C71924100 @default.
• W2314559944 hasConceptScore W2314559944C75920679 @default.
• W2314559944 hasConceptScore W2314559944C86803240 @default.
• W2314559944 hasIssue "3" @default.
• W2314559944 hasLocation W23145599441 @default.
• W2314559944 hasLocation W23145599442 @default.
• W2314559944 hasOpenAccess W2314559944 @default.
• W2314559944 hasPrimaryLocation W23145599441 @default.
• W2314559944 hasRelatedWork W1979069040 @default.
• W2314559944 hasRelatedWork W2081378286 @default.
• W2314559944 hasRelatedWork W2090196383 @default.
• W2314559944 hasRelatedWork W2141173106 @default.
• W2314559944 hasRelatedWork W2367251248 @default.
• W2314559944 hasRelatedWork W2381354186 @default.
• W2314559944 hasRelatedWork W30138332 @default.
• W2314559944 hasRelatedWork W3030075727 @default.

• next