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- W2314567907 abstract "B54 Background Men with a family history (FH) of prostate cancer (PCA) and African American (AA) men are at 2 to 7-fold increased risk for the disease. Assessing risk for PCA in these high-risk men has been challenging due to the lack of available genetic testing. Recently, five genetic single nucleotide polymorphisms (SNPs) at chromosomal loci 8q and 17q (rs1859962, rs6983267, rs4430796, rs1447295, and rs16901979) were found to have a cumulative increased association with PCA in multiple studies. These genetic variants need to be characterized in screening populations to determine their utility in the early detection of PCA. The Prostate Cancer Risk Assessment Program (PRAP) at Fox Chase Cancer Center is a prospective screening program for high-risk men. Currently there are over 700 participants, and 60% are AA. This study evaluates the clinical characteristics of high-risk men carrying these risk SNPs and time to PCA diagnosis based on the presence of these 8q/17q risk markers. Methods Eligibility for PRAP includes men ages 35-69 years with one first degree relative with PCA, two second degree relatives with PCA on the same side of the family, any AA man regardless of FH of PCA, and men with BRCA1/2 mutations. Current criteria for biopsy include PSA > 2.0 ng/mL, PSA 1.5-2.0 ng/mL with free PSA Results Genotypes for all five SNPs was able to be determined on 633 PRAP participants of whom 60% were AA. Average follow-up for these participants in PRAP has been 3-4 years. There was a statistically significant difference in the baseline distribution of risk alleles and risk genotypes of these five SNPs within self-reported race groups (p Conclusions Five genetic risk markers at 8q/17q may be useful in tailoring screening approaches in high-risk men, particularly AA men. Further follow-up is needed to firmly determine how these risk markers influence time to PCA diagnosis. Citation Information: Cancer Prev Res 2008;1(7 Suppl):B54." @default.
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- W2314567907 date "2008-11-01" @default.
- W2314567907 modified "2023-09-26" @default.
- W2314567907 title "Abstract B54: Prostate cancer screening characteristics in high-risk men with genetic risk markers at 8q and 17q" @default.
- W2314567907 doi "https://doi.org/10.1158/1940-6207.prev-08-b54" @default.
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