Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314572531> ?p ?o ?g. }
- W2314572531 endingPage "388" @default.
- W2314572531 startingPage "377" @default.
- W2314572531 abstract "Immune imbalance in autoimmune disorders such as type 1 diabetes may originate from aberrant activities of effector cells or dysfunction of suppressor cells. All possible defective mechanisms have been proposed for diabetes-prone species: (i) quantitative dominance of diabetogenic cells and decreased numbers of regulatory T cells, (ii) excessive aggression of effectors and defective function of suppressors, (iii) perturbed interaction between effector and suppressor cells, and (iv) variations in sensitivity to negative regulation. The experimental evidence available to date presents conflicting information on these mechanisms, with identification of perturbed equilibrium on the one hand and negation of critical role of each mechanism in propagation of diabetic autoimmunity on the other hand. In our analysis, there is no evidence that inherent abnormalities in numbers and function of effector and suppressor T cells are responsible for the immune imbalance responsible for propagation of type 1 diabetes as a chronic inflammatory process. Possibly, the experimental tools for investigation of these features of immune activity are still underdeveloped and lack sufficient resolution, in the presence of the extensive biological viability and functional versatility of effector and suppressor elements." @default.
- W2314572531 created "2016-06-24" @default.
- W2314572531 creator A5061768924 @default.
- W2314572531 date "2016-02-08" @default.
- W2314572531 modified "2023-10-15" @default.
- W2314572531 title "Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation" @default.
- W2314572531 cites W142989524 @default.
- W2314572531 cites W1483718683 @default.
- W2314572531 cites W1497248898 @default.
- W2314572531 cites W1498917551 @default.
- W2314572531 cites W1502231367 @default.
- W2314572531 cites W1507845819 @default.
- W2314572531 cites W1509117621 @default.
- W2314572531 cites W1511359439 @default.
- W2314572531 cites W1517524419 @default.
- W2314572531 cites W1521451515 @default.
- W2314572531 cites W1541398017 @default.
- W2314572531 cites W1543915242 @default.
- W2314572531 cites W1558376983 @default.
- W2314572531 cites W1560702178 @default.
- W2314572531 cites W1562291393 @default.
- W2314572531 cites W1563641110 @default.
- W2314572531 cites W1564622887 @default.
- W2314572531 cites W1565674752 @default.
- W2314572531 cites W1567420244 @default.
- W2314572531 cites W1574544765 @default.
- W2314572531 cites W1577058011 @default.
- W2314572531 cites W1578352430 @default.
- W2314572531 cites W1585992677 @default.
- W2314572531 cites W1586126658 @default.
- W2314572531 cites W1662182196 @default.
- W2314572531 cites W1732290849 @default.
- W2314572531 cites W1757921042 @default.
- W2314572531 cites W1787048953 @default.
- W2314572531 cites W1794377913 @default.
- W2314572531 cites W1910262301 @default.
- W2314572531 cites W1910525326 @default.
- W2314572531 cites W1911945597 @default.
- W2314572531 cites W1924286396 @default.
- W2314572531 cites W1926898654 @default.
- W2314572531 cites W1931194348 @default.
- W2314572531 cites W1946976081 @default.
- W2314572531 cites W1963764926 @default.
- W2314572531 cites W1964010927 @default.
- W2314572531 cites W1964787243 @default.
- W2314572531 cites W1965107806 @default.
- W2314572531 cites W1965296830 @default.
- W2314572531 cites W1965673490 @default.
- W2314572531 cites W1965826070 @default.
- W2314572531 cites W1965917640 @default.
- W2314572531 cites W1970700859 @default.
- W2314572531 cites W1974003730 @default.
- W2314572531 cites W1979966334 @default.
- W2314572531 cites W1981365528 @default.
- W2314572531 cites W1982761604 @default.
- W2314572531 cites W1984909066 @default.
- W2314572531 cites W1985630443 @default.
- W2314572531 cites W1987528256 @default.
- W2314572531 cites W1988928779 @default.
- W2314572531 cites W1989090634 @default.
- W2314572531 cites W1990379381 @default.
- W2314572531 cites W1994238123 @default.
- W2314572531 cites W1996465395 @default.
- W2314572531 cites W2001895690 @default.
- W2314572531 cites W2002726823 @default.
- W2314572531 cites W2002773091 @default.
- W2314572531 cites W2003080421 @default.
- W2314572531 cites W2004285547 @default.
- W2314572531 cites W2004975321 @default.
- W2314572531 cites W2007137778 @default.
- W2314572531 cites W2007673642 @default.
- W2314572531 cites W2009077163 @default.
- W2314572531 cites W2009644494 @default.
- W2314572531 cites W2013457508 @default.
- W2314572531 cites W2013572253 @default.
- W2314572531 cites W2015028960 @default.
- W2314572531 cites W2016997250 @default.
- W2314572531 cites W2017436790 @default.
- W2314572531 cites W2019060341 @default.
- W2314572531 cites W2019863970 @default.
- W2314572531 cites W2021713059 @default.
- W2314572531 cites W2021951643 @default.
- W2314572531 cites W2024189251 @default.
- W2314572531 cites W2026836824 @default.
- W2314572531 cites W2028421750 @default.
- W2314572531 cites W2028479654 @default.
- W2314572531 cites W2030963386 @default.
- W2314572531 cites W2033078418 @default.
- W2314572531 cites W2036917525 @default.
- W2314572531 cites W2038674673 @default.
- W2314572531 cites W2038743201 @default.
- W2314572531 cites W2041266914 @default.
- W2314572531 cites W2041943509 @default.
- W2314572531 cites W2042227130 @default.
- W2314572531 cites W2042844150 @default.
- W2314572531 cites W2043280981 @default.
- W2314572531 cites W2045932062 @default.
- W2314572531 cites W2046338377 @default.