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• W2314600575 abstract "Aromatic amines are widely distributed in the environment and are major environmental pollutants. Although degradation of aromatic amines is well studied in bacteria, physiological adaptations and stress response to these toxic compounds is not yet fully understood. In the present study, systemic responses of Rubrivivax benzoatilyticus JA2 to aniline stress were deciphered using metabolite and iTRAQ-labeled protein profiling. Strain JA2 tolerated high concentrations of aniline (30 mM) with trace amounts of aniline being transformed to acetanilide. GC-MS metabolite profiling revealed aniline stress phenotype wherein amino acid, carbohydrate, fatty acid, nitrogen metabolisms, and TCA (tricarboxylic acid cycle) were modulated. Strain JA2 responded to aniline by remodeling the proteome, and cellular functions, such as signaling, transcription, translation, stress tolerance, transport and carbohydrate metabolism, were highly modulated. Key adaptive responses, such as transcription/translational changes, molecular chaperones to control protein folding, and efflux pumps implicated in solvent extrusion, were induced in response to aniline stress. Proteo-metabolomics indicated extensive rewiring of metabolism to aniline. TCA cycle and amino acid catabolism were down-regulated while gluconeogenesis and pentose phosphate pathways were up-regulated, leading to the synthesis of extracellular polymeric substances. Furthermore, increased saturated fatty acid ratios in membranes due to aniline stress suggest membrane adaptation. The present study thus indicates that strain JA2 employs multilayered responses: stress response, toxic compound tolerance, energy conservation, and metabolic rearrangements to aniline." @default.
• W2314600575 created "2016-06-24" @default.
• W2314600575 creator A5040745601 @default.
• W2314600575 creator A5054041329 @default.
• W2314600575 creator A5073158705 @default.
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• W2314600575 date "2014-12-02" @default.
• W2314600575 modified "2023-09-26" @default.
• W2314600575 title "Integrated Metabolomic and Proteomic Analysis Reveals Systemic Responses of <i>Rubrivivax benzoatilyticus</i> JA2 to Aniline Stress" @default.
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• W2314600575 doi "https://doi.org/10.1021/pr500725b" @default.
• W2314600575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25388363" @default.
• W2314600575 hasPublicationYear "2014" @default.
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