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• W2314638448 abstract "PP-30-038 Background/Aims: Increased risks of cerebrovascular events from long-term ambient air pollution have been documented in a few studies. These studies have had limited ability to assign pollution levels at a high spatial resolution. Land-use regression (LUR) can predict small-scale spatial variations of air pollution that is not captured by fixed-site monitors. Previously, we documented positive associations between long-term measures of ambient NO2 from fixed-site monitors and hemorrhagic stroke, but not transient ischemic attacks (TIA) in Edmonton, Alberta. In this study, we investigate the relationship between longer term measures of NO2 from an LUR model, on hospitalization for hemorrhagic stroke. Methods: LUR estimates for NO2 in Edmonton were calibrated against data collected at 50 sampling locations during two 14-day sampling sessions in 2008. Predictor variables included the following: proximity to city center, industrial areas, major roads, highways, and water. The model R2 was 0.81. Cerebrovascular outcomes were identified on the basis of discharge diagnoses for hemorrhagic stroke (ICD-10 160–162) and TIA (G45) from Edmonton area hospitals between 2003 and 2007. Patient data included the following: age, sex, and residential postal code. We estimated the risk for hemorrhagic stroke that corresponded to an interquartile range (IQR) increase in NO2 with TIA patients as the control group. Results: In total, there were 1362 hemorrhagic stroke patients and 2651 controls. The mean (IQR) NO2 exposure for the study population was 15.4 (4.00) ppb. After adjustment for age and sex, an IQR increase in NO2 was associated with an increase of 12.3% (95% CI: 2.1%–23.6%). Conclusion: Our findings suggest that traffic pollution, as indicated by ambient NO2, increases the likelihood for a presentation with hemorrhagic stroke relative to TIA, although residual confounding by socioeconomic or other spatially variable factors cannot be ruled out. Further investigation needs to explore possible effect modification from other risk factors." @default.
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• W2314638448 date "2011-01-01" @default.
• W2314638448 modified "2023-10-14" @default.
• W2314638448 title "A Case-control Study of Ambient NO2 and Hemorrhagic Stroke in Edmonton, Canada" @default.
• W2314638448 doi "https://doi.org/10.1097/01.ede.0000392341.95011.b9" @default.
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