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• W2314640382 abstract "血管新生阻害剤TNP-470のcolon-26に対する増殖抑制効果につき検討した.方法 : 1) in vitro試験.colon-26 (5×104) をcontrol, 1, 10, 100ng/mlのTNPで処理し、増殖抑制能, 細胞周期、cyclin D 1 m-RNAの発現につき検討した.2) in vivo試験.BALB/cの腸間膜静脈よりcolon-26 (1×104) を移植、肝転移を作成, control, 1, 5, 10,100mg/kgのTNP濃度で肝転移抑制効果につき検討した.結果 : 1) in vitro. day 7における細胞数 (×104) は, 10ng/ml : 457.0±36.7, 100ng/ml : 57.0±26.6と100ng/ml以上では, 細胞増殖は抑制された (p<0.01).また100ng/ml以上では, 細胞周期はG1期が増加し, S期は減少し (p<0.05), cyclin D 1 m-RNAの発現は抑制された, 2) in vivo. day 17での肝転移個数は, control : 5.7±1.5, 5mg/kg : 1.3±1.5と5mg/kg以上では肝転移は抑制された.結語 : TNPは100ng/ml以上で有意にcolon-26の増殖を抑制し, この作用はcyclin D 1の発現の抑制によるG1期への移行の阻害と考えられた." @default.
• W2314640382 created "2016-06-24" @default.
• W2314640382 creator A5047703986 @default.
• W2314640382 date "1996-01-01" @default.
• W2314640382 modified "2023-09-26" @default.
• W2314640382 title "The Inhibitory Effect of Angiogenesis Inhibitor TNP-470 on Proliferation and Liver Metastasis of Colon-26 Cells in vitro and in vivo." @default.
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• W2314640382 doi "https://doi.org/10.3862/jcoloproctology.49.101" @default.
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