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- W2314670345 abstract "Interferon (IFN)-γ and tumor necrosis factor (TNF)-α production and lymphocyte proliferation in response to herpes simplex virus (HSV) antigen were assessed in 13 neonates and 3 parturient women with primary HSV infection. In comparison with 9 nonparturient adults, the neonates and parturient women showed significantly (P < .01) diminished HSV antigen-stimulated lymphocyte proliferation and IFN-γ production in the first 3–6 weeks after onset of infection. TNFα production did not differ significantly among HSV-infected groups. The impairment in neonatal cellular immunity was due, at least in part, to a specific deficit in response to HSV antigen. Lymphocyte proliferation and TNFα production in response to the mitogen concanavalin A (ConA) were comparable in adults and infants, but ConA-stimulated IFN-γ production in infants was diminished throughout the study period. In contrast, HSV antigen-stimulated IFN-γ production was comparable in infants and adults after 6 weeks. Not all patients with diminished cellular immune responses to HSV antigen manifested severe clinical disease. Nevertheless, patients with significant clinical morbidity had diminished cellular immune responses to HSV antigen. These results suggest that delayed acquisition of antigen-specific cellular immunity in primary HSV infection predisposes to more severe clinical disease." @default.
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- W2314670345 date "1992-05-01" @default.
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- W2314670345 title "Diminished Interferon- and Lymphocyte Proliferation in Neonatal and Postpartum Primary Herpes Simplex Virus Infection" @default.
- W2314670345 doi "https://doi.org/10.1093/infdis/165.5.813" @default.
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