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- W2314673651 abstract "This study aimed to investigate the anti-depressant effect of hesperidin (Hsp) in streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of Hsp on hyperglycaemia, oxidative stress, inflammation, brain-derived neurotrophic factor (BDNF), and brain monoamines in diabetic rats was also assessed. The Wistar rats in the experimental groups were rendered hyperglycaemic with a single dose of STZ (52.5 mg·(kg body mass) −1 , by intraperitoneal injection). The normal group received the vehicle only. Hyperglycaemic rats were treated with Hsp (25.0, 50.0, or 100.0 mg·(kg body mass) −1 ·day −1 , per oral) and fluoxetine (Flu) (5.0 mg·(kg body mass) −1 ·day −1 , per oral) 48 h after the STZ injection, for 21 consecutive days. The normal and STZ control groups received the vehicle (distilled water). Behavioral and biochemical parameters were then assessed. When Hsp was administered to the STZ-treated rats, this reversed the STZ-induced increase in immobility duration in the forced swimming test (FST) and attenuated hyperglycaemia, decreased malondialdehyde (MDA), increased reduced glutathione (GSH) decreased interleukin-6 (IL-6), and increased BDNF levels in the brain. Treatment with Hsp attenuated STZ-induced neurochemical alterations, as indicated by increased levels of monoamines in the brain, namely, norepinephrine (NE), dopamine (DA), and serotonin (5-hydroxytryptamine; 5-HT). All of these effects of Hsp were similar to those observed with the established anti-depressant Flu. This study shows that Hsp exerted anti-depressant effect in diabetic rats, which may have been partly mediated by its amelioration of hyperglycaemia as well as its anti-oxidant and anti-inflammatory activities, the enhancement of neurogenesis, and changes in the levels of monoamines in the brain." @default.
- W2314673651 created "2016-06-24" @default.
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- W2314673651 date "2014-11-01" @default.
- W2314673651 modified "2023-10-06" @default.
- W2314673651 title "Anti-depressant effect of hesperidin in diabetic rats" @default.
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- W2314673651 cites W1966797670 @default.
- W2314673651 cites W1969902527 @default.
- W2314673651 cites W1973386992 @default.
- W2314673651 cites W1974605151 @default.
- W2314673651 cites W1976653726 @default.
- W2314673651 cites W1986254047 @default.
- W2314673651 cites W1989622995 @default.
- W2314673651 cites W1991454458 @default.
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- W2314673651 cites W1996454121 @default.
- W2314673651 cites W1996894801 @default.
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- W2314673651 cites W2011224269 @default.
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- W2314673651 cites W2037909938 @default.
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- W2314673651 doi "https://doi.org/10.1139/cjpp-2014-0281" @default.
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