Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314698567> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2314698567 endingPage "820" @default.
- W2314698567 startingPage "814" @default.
- W2314698567 abstract "To observe the effects of Guanxinkang (GXK) decoction, a compound traditional Chinese herbal medicine, on expressions of peroxisome proliferator-activated receptor γ (PPARγ), liver X receptor α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) in apolipoprotein E (ApoE)-knockout mice with atherosclerosis.Fourteen 6-week-old C57BL/6 J mice were used as normal control group. Seventy 6-week-old ApoE-knockout mice receiving a high-cholesterol diet to induce atherosclerosis were randomly divided into untreated group, simvastatin group and low-dose (concentration of crude drugs at 0.864 g/mL), medium-dose (crude drugs at 1.728 g/mL) and high-dose (crude drugs at 3.456 g/mL) GXK groups. After treated with the drugs for eight weeks continuously, the livers and aortas of mice were separated. The expressions of PPARγ, LXRα and ABCA1 were measured by real-time quantitative polymerase chain reaction and Western blotting respectively.Compared with the normal control group, mRNAs and proteins of PPARγ, LXRα and ABCA1 over-expressed in the untreated group (P<0.05). After the treatment, GXK decoction and simvastatin decreased the expressions of PPARγ, LXRα and ABCA1 (P<0.05). High-dose GXK decoction had more marked effects than low- and medium-dose GXK and simvastatin.The PPARγ-LXRα-ABCA1 pathway is involved in lipid regulation and inflammation activities. Over-expression of the genes has complicated effects on atherosclerosis in ApoE-knockout mice with high-cholesterol diet. GXK decoction has anti-inflammatory and anti-matrix metalloproteinase activities by regulating PPARγ, LXRα and ABCA1 interactions in the ApoE-knockout mice." @default.
- W2314698567 created "2016-06-24" @default.
- W2314698567 creator A5007408696 @default.
- W2314698567 creator A5030525850 @default.
- W2314698567 creator A5035239799 @default.
- W2314698567 creator A5046078938 @default.
- W2314698567 creator A5077153113 @default.
- W2314698567 date "2012-07-15" @default.
- W2314698567 modified "2023-10-16" @default.
- W2314698567 title "Effects of Chinese herbal medicine Guanxinkang on expression of PPARγ-LXRα-ABCA1 pathway in ApoE-knockout mice with atherosclerosis" @default.
- W2314698567 cites W1976621212 @default.
- W2314698567 cites W2015805615 @default.
- W2314698567 cites W2024851295 @default.
- W2314698567 cites W2039855201 @default.
- W2314698567 cites W2043461724 @default.
- W2314698567 cites W2057325961 @default.
- W2314698567 cites W2099632438 @default.
- W2314698567 cites W2137506791 @default.
- W2314698567 cites W2141556979 @default.
- W2314698567 cites W2314694631 @default.
- W2314698567 cites W2387022410 @default.
- W2314698567 doi "https://doi.org/10.3736/jcim20120713" @default.
- W2314698567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22805089" @default.
- W2314698567 hasPublicationYear "2012" @default.
- W2314698567 type Work @default.
- W2314698567 sameAs 2314698567 @default.
- W2314698567 citedByCount "3" @default.
- W2314698567 countsByYear W23146985672014 @default.
- W2314698567 countsByYear W23146985672021 @default.
- W2314698567 crossrefType "journal-article" @default.
- W2314698567 hasAuthorship W2314698567A5007408696 @default.
- W2314698567 hasAuthorship W2314698567A5030525850 @default.
- W2314698567 hasAuthorship W2314698567A5035239799 @default.
- W2314698567 hasAuthorship W2314698567A5046078938 @default.
- W2314698567 hasAuthorship W2314698567A5077153113 @default.
- W2314698567 hasConcept C104317684 @default.
- W2314698567 hasConcept C126322002 @default.
- W2314698567 hasConcept C134018914 @default.
- W2314698567 hasConcept C149011108 @default.
- W2314698567 hasConcept C167400880 @default.
- W2314698567 hasConcept C170493617 @default.
- W2314698567 hasConcept C182704531 @default.
- W2314698567 hasConcept C185592680 @default.
- W2314698567 hasConcept C187345961 @default.
- W2314698567 hasConcept C190409667 @default.
- W2314698567 hasConcept C2776329913 @default.
- W2314698567 hasConcept C2776914184 @default.
- W2314698567 hasConcept C2777704780 @default.
- W2314698567 hasConcept C2778163477 @default.
- W2314698567 hasConcept C2779134260 @default.
- W2314698567 hasConcept C55493867 @default.
- W2314698567 hasConcept C57089818 @default.
- W2314698567 hasConcept C63932345 @default.
- W2314698567 hasConcept C71924100 @default.
- W2314698567 hasConcept C86339819 @default.
- W2314698567 hasConcept C98274493 @default.
- W2314698567 hasConceptScore W2314698567C104317684 @default.
- W2314698567 hasConceptScore W2314698567C126322002 @default.
- W2314698567 hasConceptScore W2314698567C134018914 @default.
- W2314698567 hasConceptScore W2314698567C149011108 @default.
- W2314698567 hasConceptScore W2314698567C167400880 @default.
- W2314698567 hasConceptScore W2314698567C170493617 @default.
- W2314698567 hasConceptScore W2314698567C182704531 @default.
- W2314698567 hasConceptScore W2314698567C185592680 @default.
- W2314698567 hasConceptScore W2314698567C187345961 @default.
- W2314698567 hasConceptScore W2314698567C190409667 @default.
- W2314698567 hasConceptScore W2314698567C2776329913 @default.
- W2314698567 hasConceptScore W2314698567C2776914184 @default.
- W2314698567 hasConceptScore W2314698567C2777704780 @default.
- W2314698567 hasConceptScore W2314698567C2778163477 @default.
- W2314698567 hasConceptScore W2314698567C2779134260 @default.
- W2314698567 hasConceptScore W2314698567C55493867 @default.
- W2314698567 hasConceptScore W2314698567C57089818 @default.
- W2314698567 hasConceptScore W2314698567C63932345 @default.
- W2314698567 hasConceptScore W2314698567C71924100 @default.
- W2314698567 hasConceptScore W2314698567C86339819 @default.
- W2314698567 hasConceptScore W2314698567C98274493 @default.
- W2314698567 hasIssue "7" @default.
- W2314698567 hasLocation W23146985671 @default.
- W2314698567 hasLocation W23146985672 @default.
- W2314698567 hasOpenAccess W2314698567 @default.
- W2314698567 hasPrimaryLocation W23146985671 @default.
- W2314698567 hasRelatedWork W1998394120 @default.
- W2314698567 hasRelatedWork W2020132910 @default.
- W2314698567 hasRelatedWork W2045878648 @default.
- W2314698567 hasRelatedWork W2079616833 @default.
- W2314698567 hasRelatedWork W2314698567 @default.
- W2314698567 hasRelatedWork W2584695841 @default.
- W2314698567 hasRelatedWork W2588206880 @default.
- W2314698567 hasRelatedWork W3196174451 @default.
- W2314698567 hasRelatedWork W342499788 @default.
- W2314698567 hasRelatedWork W2103202785 @default.
- W2314698567 hasVolume "10" @default.
- W2314698567 isParatext "false" @default.
- W2314698567 isRetracted "false" @default.
- W2314698567 magId "2314698567" @default.
- W2314698567 workType "article" @default.