Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314699129> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2314699129 endingPage "504" @default.
- W2314699129 startingPage "502" @default.
- W2314699129 abstract "The pathogenic activity of microörganisms may be due to toxic substances of either cellular or extracellular nature or both. These substances are usually designated endotoxin and exotoxin, although it is likely that no sharp division line exists. An ideal antigen for active immunization in the case of invasive microörganisms, which produce both endo- and exotoxin, should contain both endo- and exotoxic principles. Likewise, an ideal antibody-solution when administered therapeutically should be able to neutralize both the endo- and exotoxin of the homologous organism. Staphylococcus pyogenes produces a soluble exotoxin which is readily converted into formol-toxoid, and is used for active immunization of laboratory animals and human beings. The staphylococcus contains endotoxin, and vaccines have been used for a long time in the prophylaxis and treatment of localized staphylococcal infections. Bacteriophage-solution is also used therapeutically, both on account of its lytic activity towards the organisms and because bacteriophagic solution of the lysed staphylococcus is antigenic. The toxoid, the vaccine, and the bacteriophagic solution may be considered as representing different antigenic groups. If an antigen embodied all these antigenic principles, the immunity would presumably be more effective than specific antitoxic immunity or a strict antibacterial immunity, and the administration of an antitoxin which in addition contained antibacterial antibodies would better match the toxin-producing and invading characteristics of S. pyogenes. Prompted by these considerations we prepared a multivalent staphylococcal toxoid which contains endotoxic as well as exotoxic principles of staphylococci. Lysis by bacteriophage was preferred to other methods in order to avoid denaturation and because the antigenic activity of bacteriophage solution is well established." @default.
- W2314699129 created "2016-06-24" @default.
- W2314699129 creator A5027974299 @default.
- W2314699129 creator A5055991332 @default.
- W2314699129 creator A5076290091 @default.
- W2314699129 date "1936-05-01" @default.
- W2314699129 modified "2023-09-25" @default.
- W2314699129 title "Combined Staphylococcal Endo- and Exo-Antigen" @default.
- W2314699129 doi "https://doi.org/10.3181/00379727-34-8676p" @default.
- W2314699129 hasPublicationYear "1936" @default.
- W2314699129 type Work @default.
- W2314699129 sameAs 2314699129 @default.
- W2314699129 citedByCount "0" @default.
- W2314699129 crossrefType "journal-article" @default.
- W2314699129 hasAuthorship W2314699129A5027974299 @default.
- W2314699129 hasAuthorship W2314699129A5055991332 @default.
- W2314699129 hasAuthorship W2314699129A5076290091 @default.
- W2314699129 hasConcept C104317684 @default.
- W2314699129 hasConcept C147483822 @default.
- W2314699129 hasConcept C159047783 @default.
- W2314699129 hasConcept C159654299 @default.
- W2314699129 hasConcept C182615771 @default.
- W2314699129 hasConcept C203014093 @default.
- W2314699129 hasConcept C2522874641 @default.
- W2314699129 hasConcept C2776441376 @default.
- W2314699129 hasConcept C2777351567 @default.
- W2314699129 hasConcept C2777367657 @default.
- W2314699129 hasConcept C2778723905 @default.
- W2314699129 hasConcept C2778943623 @default.
- W2314699129 hasConcept C2778973234 @default.
- W2314699129 hasConcept C2779288629 @default.
- W2314699129 hasConcept C2779341262 @default.
- W2314699129 hasConcept C2779489039 @default.
- W2314699129 hasConcept C2780801004 @default.
- W2314699129 hasConcept C523546767 @default.
- W2314699129 hasConcept C54355233 @default.
- W2314699129 hasConcept C547475151 @default.
- W2314699129 hasConcept C55493867 @default.
- W2314699129 hasConcept C86803240 @default.
- W2314699129 hasConcept C8891405 @default.
- W2314699129 hasConcept C89423630 @default.
- W2314699129 hasConceptScore W2314699129C104317684 @default.
- W2314699129 hasConceptScore W2314699129C147483822 @default.
- W2314699129 hasConceptScore W2314699129C159047783 @default.
- W2314699129 hasConceptScore W2314699129C159654299 @default.
- W2314699129 hasConceptScore W2314699129C182615771 @default.
- W2314699129 hasConceptScore W2314699129C203014093 @default.
- W2314699129 hasConceptScore W2314699129C2522874641 @default.
- W2314699129 hasConceptScore W2314699129C2776441376 @default.
- W2314699129 hasConceptScore W2314699129C2777351567 @default.
- W2314699129 hasConceptScore W2314699129C2777367657 @default.
- W2314699129 hasConceptScore W2314699129C2778723905 @default.
- W2314699129 hasConceptScore W2314699129C2778943623 @default.
- W2314699129 hasConceptScore W2314699129C2778973234 @default.
- W2314699129 hasConceptScore W2314699129C2779288629 @default.
- W2314699129 hasConceptScore W2314699129C2779341262 @default.
- W2314699129 hasConceptScore W2314699129C2779489039 @default.
- W2314699129 hasConceptScore W2314699129C2780801004 @default.
- W2314699129 hasConceptScore W2314699129C523546767 @default.
- W2314699129 hasConceptScore W2314699129C54355233 @default.
- W2314699129 hasConceptScore W2314699129C547475151 @default.
- W2314699129 hasConceptScore W2314699129C55493867 @default.
- W2314699129 hasConceptScore W2314699129C86803240 @default.
- W2314699129 hasConceptScore W2314699129C8891405 @default.
- W2314699129 hasConceptScore W2314699129C89423630 @default.
- W2314699129 hasIssue "4" @default.
- W2314699129 hasLocation W23146991291 @default.
- W2314699129 hasOpenAccess W2314699129 @default.
- W2314699129 hasPrimaryLocation W23146991291 @default.
- W2314699129 hasRelatedWork W1979549213 @default.
- W2314699129 hasRelatedWork W2024716824 @default.
- W2314699129 hasRelatedWork W2094137434 @default.
- W2314699129 hasRelatedWork W2109355858 @default.
- W2314699129 hasRelatedWork W2152655939 @default.
- W2314699129 hasRelatedWork W2314699129 @default.
- W2314699129 hasRelatedWork W2329311130 @default.
- W2314699129 hasRelatedWork W2551242820 @default.
- W2314699129 hasRelatedWork W2965522752 @default.
- W2314699129 hasRelatedWork W4281634382 @default.
- W2314699129 hasVolume "34" @default.
- W2314699129 isParatext "false" @default.
- W2314699129 isRetracted "false" @default.
- W2314699129 magId "2314699129" @default.
- W2314699129 workType "article" @default.