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• W2314712188 abstract "Drosophila intestinal stem cells (ISCs) generate enterocytes (ECs) and enteroendocrine (ee) cells. Previous work suggests that different levels of the Notch ligand Delta (Dl) in ISCs unidirectionally activate Notch in daughters to control multipotency. However, the mechanisms driving different outcomes remain unknown. We found that during ee cell formation, the ee cell marker Prospero localizes to the basal side of dividing ISCs. After asymmetric division, the ee daughter cell acts as a source of Dl that induces low Notch activity in the ISC to maintain identity. Alternatively, ISCs expressing Dl induce high Notch activity in daughter cells to promote EC formation. Our data reveal a conserved role for Notch in Drosophila and mammalian ISC maintenance and suggest that bidirectional Notch signaling may regulate multipotency in other systems." @default.
• W2314712188 created "2016-06-24" @default.
• W2314712188 creator A5061224769 @default.
• W2314712188 creator A5070741632 @default.
• W2314712188 date "2015-11-20" @default.
• W2314712188 modified "2023-10-16" @default.
• W2314712188 title "Bidirectional Notch signaling regulates <i>Drosophila</i> intestinal stem cell multipotency" @default.
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• W2314712188 doi "https://doi.org/10.1126/science.aab0988" @default.
• W2314712188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5431284" @default.
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• W2314712188 hasPublicationYear "2015" @default.
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