FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314723437> ?p ?o ?g. }

• W2314723437 endingPage "2302" @default.
• W2314723437 startingPage "2292" @default.
• W2314723437 abstract "We report the antitumor effects of nitric oxide (NO) releasing derivatives of the PARP-1 inhibitor olaparib (1). Compound 5b was prepared by coupling the carboxyl group of 3b and the free amino group of arylated diazeniumdiolated piperazine 4. Analogue 5a has the same structure except that the F is replaced by H. Compound 13 is the same as 5b except that a Me2N-N(O)═NO- group was added para and ortho to the nitro groups of the dinitrophenyl ring. The resulting prodrugs are activated by glutathione in a reaction accelerated by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancers. This metabolism generates NO plus a PARP-1 inhibitor simultaneously, consuming reducing equivalents, leading to DNA damage concomitant with inhibition of DNA repair, and in the case of 13 inducing cross-linking glutathionylation of proteins. Compounds 5b and 13 reduced the growth rates of A549 human lung adenocarcinoma xenografts with no evidence of systemic toxicity." @default.
• W2314723437 created "2016-06-24" @default.
• W2314723437 creator A5000314948 @default.
• W2314723437 creator A5002271964 @default.
• W2314723437 creator A5002470025 @default.
• W2314723437 creator A5037710598 @default.
• W2314723437 creator A5040241398 @default.
• W2314723437 creator A5041541292 @default.
• W2314723437 creator A5045226105 @default.
• W2314723437 creator A5069231811 @default.
• W2314723437 creator A5069348197 @default.
• W2314723437 creator A5069407758 @default.
• W2314723437 creator A5076715400 @default.
• W2314723437 creator A5078389294 @default.
• W2314723437 date "2014-02-25" @default.
• W2314723437 modified "2023-09-29" @default.
• W2314723437 title "Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells" @default.
• W2314723437 cites W1967517379 @default.
• W2314723437 cites W1970451442 @default.
• W2314723437 cites W1992509675 @default.
• W2314723437 cites W1994125700 @default.
• W2314723437 cites W1994432408 @default.
• W2314723437 cites W2014035904 @default.
• W2314723437 cites W2018205505 @default.
• W2314723437 cites W2018690104 @default.
• W2314723437 cites W2022959259 @default.
• W2314723437 cites W2046504033 @default.
• W2314723437 cites W2049462428 @default.
• W2314723437 cites W2061575685 @default.
• W2314723437 cites W2063266714 @default.
• W2314723437 cites W2065685888 @default.
• W2314723437 cites W2066225361 @default.
• W2314723437 cites W2073178202 @default.
• W2314723437 cites W2073213695 @default.
• W2314723437 cites W2081510209 @default.
• W2314723437 cites W2082822526 @default.
• W2314723437 cites W2084925682 @default.
• W2314723437 cites W2089554370 @default.
• W2314723437 cites W2096843793 @default.
• W2314723437 doi "https://doi.org/10.1021/jm401550d" @default.
• W2314723437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3983374" @default.
• W2314723437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521039" @default.
• W2314723437 hasPublicationYear "2014" @default.
• W2314723437 type Work @default.
• W2314723437 sameAs 2314723437 @default.
• W2314723437 citedByCount "35" @default.
• W2314723437 countsByYear W23147234372014 @default.
• W2314723437 countsByYear W23147234372015 @default.
• W2314723437 countsByYear W23147234372016 @default.
• W2314723437 countsByYear W23147234372017 @default.
• W2314723437 countsByYear W23147234372018 @default.
• W2314723437 countsByYear W23147234372019 @default.
• W2314723437 countsByYear W23147234372020 @default.
• W2314723437 countsByYear W23147234372021 @default.
• W2314723437 countsByYear W23147234372022 @default.
• W2314723437 countsByYear W23147234372023 @default.
• W2314723437 crossrefType "journal-article" @default.
• W2314723437 hasAuthorship W2314723437A5000314948 @default.
• W2314723437 hasAuthorship W2314723437A5002271964 @default.
• W2314723437 hasAuthorship W2314723437A5002470025 @default.
• W2314723437 hasAuthorship W2314723437A5037710598 @default.
• W2314723437 hasAuthorship W2314723437A5040241398 @default.
• W2314723437 hasAuthorship W2314723437A5041541292 @default.
• W2314723437 hasAuthorship W2314723437A5045226105 @default.
• W2314723437 hasAuthorship W2314723437A5069231811 @default.
• W2314723437 hasAuthorship W2314723437A5069348197 @default.
• W2314723437 hasAuthorship W2314723437A5069407758 @default.
• W2314723437 hasAuthorship W2314723437A5076715400 @default.
• W2314723437 hasAuthorship W2314723437A5078389294 @default.
• W2314723437 hasBestOaLocation W23147234371 @default.
• W2314723437 hasConcept C108215921 @default.
• W2314723437 hasConcept C143425029 @default.
• W2314723437 hasConcept C178790620 @default.
• W2314723437 hasConcept C181199279 @default.
• W2314723437 hasConcept C182979987 @default.
• W2314723437 hasConcept C185592680 @default.
• W2314723437 hasConcept C2779138821 @default.
• W2314723437 hasConcept C2779962180 @default.
• W2314723437 hasConcept C519581460 @default.
• W2314723437 hasConcept C538909803 @default.
• W2314723437 hasConcept C552990157 @default.
• W2314723437 hasConcept C55493867 @default.
• W2314723437 hasConcept C71240020 @default.
• W2314723437 hasConcept C71924100 @default.
• W2314723437 hasConcept C82381507 @default.
• W2314723437 hasConcept C98274493 @default.
• W2314723437 hasConceptScore W2314723437C108215921 @default.
• W2314723437 hasConceptScore W2314723437C143425029 @default.
• W2314723437 hasConceptScore W2314723437C178790620 @default.
• W2314723437 hasConceptScore W2314723437C181199279 @default.
• W2314723437 hasConceptScore W2314723437C182979987 @default.
• W2314723437 hasConceptScore W2314723437C185592680 @default.
• W2314723437 hasConceptScore W2314723437C2779138821 @default.
• W2314723437 hasConceptScore W2314723437C2779962180 @default.
• W2314723437 hasConceptScore W2314723437C519581460 @default.
• W2314723437 hasConceptScore W2314723437C538909803 @default.
• W2314723437 hasConceptScore W2314723437C552990157 @default.
• W2314723437 hasConceptScore W2314723437C55493867 @default.

• next