Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314749665> ?p ?o ?g. }
- W2314749665 abstract "This study evaluated the association of the anti-angiogenic SPARC with known angiogenesis-associated factors and diabetes-related micro- and macro-vascular complications in a Singapore Chinese cohort with type 2 diabetes (T2DM).Plasma SPARC was measured by immunoassay in 438 T2DM adults (mean age:58±11years).Higher SPARC levels in subjects stratified by SPARC tertiles displayed decreased pro-angiogenic adiponectin, osteopontin, vascular cell adhesion molecule (VCAM)-1 and matrix metalloproteinase (MMP)-2 concentrations (all p<0.05). The anti-angiogenic pigment epithelium-derived factor (PEDF) level was not statistically different among the SPARC tertiles. Age-adjusted partial correlation revealed significant associations of SPARC with adiponectin, osteopontin, VCAM-1, MMP-2, and PEDF (all p<0.05). Lower SPARC was accompanied by less favorable estimated glomerular filtration rate (eGFR) and carotid-femoral pulse wave velocity (PWV) readings (all p<0.05). Conversely, ankle-brachial index (ABI) reduced with increasing SPARC (p=0.048). The eGFR (B=0.834, p=0.019), PWV (B=-7.925, p=0.009), and ABI (B=-142.160, p=0.010) remained as determinants of SPARC after confounder adjustment. Moreover, individuals in the lowest SPARC tertile had increased odds of aortic stiffness (OR=1.900, 95% CI=1.103-3.274) but reduced odds of peripheral arterial disease (OR=0.400, 95% CI=0.175-0.919). However, SPARC was not independently associated with chronic kidney disease.The anti-angiogenic SPARC may be associated with the pathophysiology of diabetes-related macrovascular complications." @default.
- W2314749665 created "2016-06-24" @default.
- W2314749665 creator A5002078336 @default.
- W2314749665 creator A5005026302 @default.
- W2314749665 creator A5011330789 @default.
- W2314749665 creator A5036039345 @default.
- W2314749665 creator A5066365214 @default.
- W2314749665 creator A5069600747 @default.
- W2314749665 creator A5075777538 @default.
- W2314749665 creator A5080640808 @default.
- W2314749665 creator A5083336568 @default.
- W2314749665 date "2017-07-01" @default.
- W2314749665 modified "2023-09-28" @default.
- W2314749665 title "Association of the anti-angiogenic factor secreted protein and rich in cysteine (SPARC) with vascular complications among Chinese type 2 diabetic patients in Singapore" @default.
- W2314749665 cites W1548672594 @default.
- W2314749665 cites W1654453027 @default.
- W2314749665 cites W1937435101 @default.
- W2314749665 cites W1963864987 @default.
- W2314749665 cites W1966654776 @default.
- W2314749665 cites W1969298821 @default.
- W2314749665 cites W1974167931 @default.
- W2314749665 cites W1977820385 @default.
- W2314749665 cites W1979243344 @default.
- W2314749665 cites W1986991414 @default.
- W2314749665 cites W1987929268 @default.
- W2314749665 cites W1993530267 @default.
- W2314749665 cites W1995324236 @default.
- W2314749665 cites W2008967025 @default.
- W2314749665 cites W2010616945 @default.
- W2314749665 cites W2013388004 @default.
- W2314749665 cites W2015682942 @default.
- W2314749665 cites W2017763556 @default.
- W2314749665 cites W2018162829 @default.
- W2314749665 cites W2018504080 @default.
- W2314749665 cites W2027078891 @default.
- W2314749665 cites W2036381935 @default.
- W2314749665 cites W2054118339 @default.
- W2314749665 cites W2056492091 @default.
- W2314749665 cites W2060814786 @default.
- W2314749665 cites W2064134286 @default.
- W2314749665 cites W2064197760 @default.
- W2314749665 cites W2081935054 @default.
- W2314749665 cites W2082457226 @default.
- W2314749665 cites W2084048949 @default.
- W2314749665 cites W2092515735 @default.
- W2314749665 cites W2096237016 @default.
- W2314749665 cites W2099266982 @default.
- W2314749665 cites W2118287673 @default.
- W2314749665 cites W2122949717 @default.
- W2314749665 cites W2129786688 @default.
- W2314749665 cites W2138209376 @default.
- W2314749665 cites W2146594207 @default.
- W2314749665 cites W2156626338 @default.
- W2314749665 cites W2157716839 @default.
- W2314749665 cites W2162674697 @default.
- W2314749665 cites W2167923070 @default.
- W2314749665 doi "https://doi.org/10.1016/j.jdiacomp.2016.03.029" @default.
- W2314749665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28479157" @default.
- W2314749665 hasPublicationYear "2017" @default.
- W2314749665 type Work @default.
- W2314749665 sameAs 2314749665 @default.
- W2314749665 citedByCount "3" @default.
- W2314749665 countsByYear W23147496652018 @default.
- W2314749665 countsByYear W23147496652020 @default.
- W2314749665 crossrefType "journal-article" @default.
- W2314749665 hasAuthorship W2314749665A5002078336 @default.
- W2314749665 hasAuthorship W2314749665A5005026302 @default.
- W2314749665 hasAuthorship W2314749665A5011330789 @default.
- W2314749665 hasAuthorship W2314749665A5036039345 @default.
- W2314749665 hasAuthorship W2314749665A5066365214 @default.
- W2314749665 hasAuthorship W2314749665A5069600747 @default.
- W2314749665 hasAuthorship W2314749665A5075777538 @default.
- W2314749665 hasAuthorship W2314749665A5080640808 @default.
- W2314749665 hasAuthorship W2314749665A5083336568 @default.
- W2314749665 hasConcept C126322002 @default.
- W2314749665 hasConcept C131075544 @default.
- W2314749665 hasConcept C134018914 @default.
- W2314749665 hasConcept C156957248 @default.
- W2314749665 hasConcept C160160445 @default.
- W2314749665 hasConcept C181199279 @default.
- W2314749665 hasConcept C185592680 @default.
- W2314749665 hasConcept C2776782570 @default.
- W2314749665 hasConcept C2777180221 @default.
- W2314749665 hasConcept C2777391703 @default.
- W2314749665 hasConcept C2778319312 @default.
- W2314749665 hasConcept C2778653478 @default.
- W2314749665 hasConcept C2780394083 @default.
- W2314749665 hasConcept C2780804394 @default.
- W2314749665 hasConcept C2781460891 @default.
- W2314749665 hasConcept C52237779 @default.
- W2314749665 hasConcept C55493867 @default.
- W2314749665 hasConcept C555293320 @default.
- W2314749665 hasConcept C71924100 @default.
- W2314749665 hasConcept C72563966 @default.
- W2314749665 hasConcept C84393581 @default.
- W2314749665 hasConceptScore W2314749665C126322002 @default.
- W2314749665 hasConceptScore W2314749665C131075544 @default.
- W2314749665 hasConceptScore W2314749665C134018914 @default.
- W2314749665 hasConceptScore W2314749665C156957248 @default.
- W2314749665 hasConceptScore W2314749665C160160445 @default.