FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314751503> ?p ?o ?g. }

• W2314751503 endingPage "291" @default.
• W2314751503 startingPage "282" @default.
• W2314751503 abstract "Administration of inhaled carbon monoxide before organ ischemic injury exerts protective effects in animal models. Because there are no data showing that this also works after an ischemic insult, our objective in this study was to investigate whether inhaled carbon monoxide attenuates cardiopulmonary bypass (CPB)-induced lung injury in a pig model.Animals were randomized to a SHAM group (n = 5), a SHAM group plus inhaled carbon monoxide (n = 5), standard CPB (n = 10), and to CPB plus inhaled carbon monoxide (n = 10). Carbon monoxide (250 ppm) was given for 1 hour after termination of CPB. Lung biopsies were obtained before CPB, immediately after separation from CPB, and for 5 hours after termination of CPB to determine expression of pulmonary heat shock proteins 70 and 90, cytokines, alveolar macrophage infiltration, and fluorogenic caspase-3 activity.At 5 hours after CPB, administration of inhaled carbon monoxide was associated with reduced pulmonary expression of the inflammatory cytokines tumor necrosis factor (CPB + CO 521 ± 77 vs CPB 821 ± 97 pg · mL(-1), P < 0.001) and interleukin-6 (304 ± 81 vs 860 ± 153 pg · mL(-1), P < 0.001), increased pulmonary expression of the cytoprotective heat shock protein 70 (CPB + CO 79 ± 14 vs CPB 36 ± 9 ng · mL(-1), P < 0.001) and the antiinflammatory cytokine interleukin-10 (CPB + CO 278 ± 40 vs CPB 63 ± 20 pg · mL(-1), P < 0.001), and with reduced pulmonary apoptotic protein caspase-3 activity (CPB + CO 0.73 ± 0.11 vs CPB 0.99 ± 0.1 RFU, P < 0.05). Carbon monoxide administration was associated with reduced histological evidence of lung injury and alveolar macrophage infiltration (78 ± 39 vs 145 ± 34 counts per field of vision, P < 0.001).These results suggest that administration of low concentrations of carbon monoxide after CPB (postconditioning) protects the lung from CPB-related lung injury." @default.
• W2314751503 created "2016-06-24" @default.
• W2314751503 creator A5003397453 @default.
• W2314751503 creator A5007450774 @default.
• W2314751503 creator A5026468988 @default.
• W2314751503 creator A5040797775 @default.
• W2314751503 creator A5050663577 @default.
• W2314751503 creator A5064095390 @default.
• W2314751503 creator A5070822264 @default.
• W2314751503 creator A5078372569 @default.
• W2314751503 date "2011-02-01" @default.
• W2314751503 modified "2023-10-18" @default.
• W2314751503 title "Postconditioning of the Lungs with Inhaled Carbon Monoxide After Cardiopulmonary Bypass in Pigs" @default.
• W2314751503 cites W1600690434 @default.
• W2314751503 cites W1965109486 @default.
• W2314751503 cites W1972526878 @default.
• W2314751503 cites W1979550998 @default.
• W2314751503 cites W1983214838 @default.
• W2314751503 cites W2000470430 @default.
• W2314751503 cites W2004604081 @default.
• W2314751503 cites W2004763695 @default.
• W2314751503 cites W2010914459 @default.
• W2314751503 cites W2011031473 @default.
• W2314751503 cites W2018563659 @default.
• W2314751503 cites W2023746083 @default.
• W2314751503 cites W2026640117 @default.
• W2314751503 cites W2028758702 @default.
• W2314751503 cites W2030310318 @default.
• W2314751503 cites W2048470272 @default.
• W2314751503 cites W2062157249 @default.
• W2314751503 cites W2069051470 @default.
• W2314751503 cites W2074773055 @default.
• W2314751503 cites W2075227608 @default.
• W2314751503 cites W2075611200 @default.
• W2314751503 cites W2103758392 @default.
• W2314751503 cites W2104622698 @default.
• W2314751503 cites W2119672041 @default.
• W2314751503 cites W2147901175 @default.
• W2314751503 cites W2155700435 @default.
• W2314751503 cites W2160738020 @default.
• W2314751503 cites W2163136650 @default.
• W2314751503 cites W2167556957 @default.
• W2314751503 cites W4245376638 @default.
• W2314751503 doi "https://doi.org/10.1213/ane.0b013e318203f591" @default.
• W2314751503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21156982" @default.
• W2314751503 hasPublicationYear "2011" @default.
• W2314751503 type Work @default.
• W2314751503 sameAs 2314751503 @default.
• W2314751503 citedByCount "12" @default.
• W2314751503 countsByYear W23147515032012 @default.
• W2314751503 countsByYear W23147515032014 @default.
• W2314751503 countsByYear W23147515032020 @default.
• W2314751503 countsByYear W23147515032021 @default.
• W2314751503 countsByYear W23147515032022 @default.
• W2314751503 countsByYear W23147515032023 @default.
• W2314751503 crossrefType "journal-article" @default.
• W2314751503 hasAuthorship W2314751503A5003397453 @default.
• W2314751503 hasAuthorship W2314751503A5007450774 @default.
• W2314751503 hasAuthorship W2314751503A5026468988 @default.
• W2314751503 hasAuthorship W2314751503A5040797775 @default.
• W2314751503 hasAuthorship W2314751503A5050663577 @default.
• W2314751503 hasAuthorship W2314751503A5064095390 @default.
• W2314751503 hasAuthorship W2314751503A5070822264 @default.
• W2314751503 hasAuthorship W2314751503A5078372569 @default.
• W2314751503 hasBestOaLocation W23147515031 @default.
• W2314751503 hasConcept C126322002 @default.
• W2314751503 hasConcept C161790260 @default.
• W2314751503 hasConcept C185592680 @default.
• W2314751503 hasConcept C2777714996 @default.
• W2314751503 hasConcept C2777961210 @default.
• W2314751503 hasConcept C2778881276 @default.
• W2314751503 hasConcept C42219234 @default.
• W2314751503 hasConcept C512735826 @default.
• W2314751503 hasConcept C55493867 @default.
• W2314751503 hasConcept C71924100 @default.
• W2314751503 hasConcept C98274493 @default.
• W2314751503 hasConceptScore W2314751503C126322002 @default.
• W2314751503 hasConceptScore W2314751503C161790260 @default.
• W2314751503 hasConceptScore W2314751503C185592680 @default.
• W2314751503 hasConceptScore W2314751503C2777714996 @default.
• W2314751503 hasConceptScore W2314751503C2777961210 @default.
• W2314751503 hasConceptScore W2314751503C2778881276 @default.
• W2314751503 hasConceptScore W2314751503C42219234 @default.
• W2314751503 hasConceptScore W2314751503C512735826 @default.
• W2314751503 hasConceptScore W2314751503C55493867 @default.
• W2314751503 hasConceptScore W2314751503C71924100 @default.
• W2314751503 hasConceptScore W2314751503C98274493 @default.
• W2314751503 hasIssue "2" @default.
• W2314751503 hasLocation W23147515031 @default.
• W2314751503 hasLocation W23147515032 @default.
• W2314751503 hasLocation W23147515033 @default.
• W2314751503 hasOpenAccess W2314751503 @default.
• W2314751503 hasPrimaryLocation W23147515031 @default.
• W2314751503 hasRelatedWork W2015371913 @default.
• W2314751503 hasRelatedWork W2315787763 @default.
• W2314751503 hasRelatedWork W2434292116 @default.
• W2314751503 hasRelatedWork W2462928754 @default.
• W2314751503 hasRelatedWork W2475369677 @default.

• next