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- W2314756711 abstract "Abstract ! Complex−regional pain syndromes (CRPS), for−merl yknown as Sudeck’s dystroph and causal−gia, belong to the neuropathic pain syndromes.CRPS may develop following fractures, limb trau−ma or lesions of the peripheral or central (CNS)nervous system. Occasionally, CRPS may also de−velop spontaneously. The clinical picture compri−ses a characteristic clinical triade of symptomsincluding autonomic (disturbances of skin tem−perature, colour, presence of sweating abnorma−lities), sensory (pain and hyperalgesia) and motor(paresis, tremor, dystonia) disturbances. Diagno−sis is mainly based on clinical signs. However, ad−ditional laboratory, neurophysiological and ra−diological examinations may help to corroboratecorrect diagnosis. Several pathophysiologicalconcepts have been proposed to explain the com−plex symptoms of CRPS: 1, facilitated neurogenicinflammation; 2, pathological sympatho−afferentcoupling; 3, neuroplastic changes within theCNS. Furthermore, there is accumulating evi−dence that genetic factors may predispose forCRPS. Therapy is based on a multidisciplinary ap−proach. Non−pharmacological approaches in−clude physiotherapy and occupational therapy.Pharmacotherapy is based on individual symp−toms and includes steroids, free radical scaven−gers, treatment of neuropathic pain, and finallyagents interfering with bone metabolism (calci−tonin, biphosphonates). Sympathetic blocks areuseful for the treatment of sympatheticallymaintained pain. Invasive therapeutic conceptsinclude implantation of spinal cord stimulators.This review covers new aspects of pathophysiolo−gy and therapy of CRPS." @default.
- W2314756711 created "2016-06-24" @default.
- W2314756711 creator A5031592308 @default.
- W2314756711 creator A5046583010 @default.
- W2314756711 date "2007-01-01" @default.
- W2314756711 modified "2023-09-26" @default.
- W2314756711 title "Komplex regionale Schmerzsyndrome : Neues zu Pathophysiologie und Therapie Complex Regional Pain Syndromes: New Aspec ts on Pathophysiology and Therapy" @default.
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