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• W2314798712 endingPage "525" @default.
• W2314798712 startingPage "516" @default.
• W2314798712 abstract "Purpose of review Aminoglycoside antibiotics (AGAs) have proved an invaluable part of our antimicrobial armamentarium since their introduction into practice over 60 years ago. This review summarizes recent developments, defining their role in the context of the current global epidemic of antibiotic resistance, raising awareness of their toxicity profile, and highlighting current data on their utility as synergistic agents. Recent findings Clinicians are facing an unprecedented threat from antibiotic resistance, resulting in an increased reliance on the addition of an AGA to provide adequate empirical cover in cases of severe sepsis. Concurrently, an increased awareness of the potential for severe disability, particularly from vestibular toxicity, has restrained directed therapy of AGAs to situations in which there are no appropriate alternatives. Their role as synergistic agents in the treatment of enterococcal endocarditis is currently under reevaluation, and new data have emerged on combination therapy for Pseudomonas aeruginosa bacteremia. AGAs are themselves coming under increasing threat from resistance, predominately from aminoglycoside modifying enzymes (mediating selective resistance) and 16S rRNA methyltransferases (conferring class-wide resistance). New agents and the development of alternate ways to circumvent resistance are likely to have important roles in future clinical care. Summary Aminoglycosides retain an invaluable but well defined role, and will remain important agents into the foreseeable future." @default.
• W2314798712 created "2016-06-24" @default.
• W2314798712 creator A5000873682 @default.
• W2314798712 creator A5022673364 @default.
• W2314798712 creator A5084749618 @default.
• W2314798712 date "2013-12-01" @default.
• W2314798712 modified "2023-10-17" @default.
• W2314798712 title "Aminoglycosides" @default.
• W2314798712 cites W1809592289 @default.
• W2314798712 cites W1892779545 @default.
• W2314798712 cites W1955530400 @default.
• W2314798712 cites W1973487717 @default.
• W2314798712 cites W1978152325 @default.
• W2314798712 cites W1978370571 @default.
• W2314798712 cites W1981564187 @default.
• W2314798712 cites W1983544635 @default.
• W2314798712 cites W1985069389 @default.
• W2314798712 cites W1985346266 @default.
• W2314798712 cites W1985901275 @default.
• W2314798712 cites W1987093371 @default.
• W2314798712 cites W1988584796 @default.
• W2314798712 cites W1988855414 @default.
• W2314798712 cites W1996122986 @default.
• W2314798712 cites W1996625076 @default.
• W2314798712 cites W199855956 @default.
• W2314798712 cites W2004380464 @default.
• W2314798712 cites W2006333306 @default.
• W2314798712 cites W2006605675 @default.
• W2314798712 cites W2006895725 @default.
• W2314798712 cites W2010504608 @default.
• W2314798712 cites W2012587300 @default.
• W2314798712 cites W2022178742 @default.
• W2314798712 cites W2023616695 @default.
• W2314798712 cites W2028744327 @default.
• W2314798712 cites W2031083926 @default.
• W2314798712 cites W2031599199 @default.
• W2314798712 cites W2032861876 @default.
• W2314798712 cites W2034013438 @default.
• W2314798712 cites W2034026426 @default.
• W2314798712 cites W2034472928 @default.
• W2314798712 cites W2035145746 @default.
• W2314798712 cites W2039704386 @default.
• W2314798712 cites W2040745787 @default.
• W2314798712 cites W2040895520 @default.
• W2314798712 cites W2046369571 @default.
• W2314798712 cites W2049149492 @default.
• W2314798712 cites W2057715967 @default.
• W2314798712 cites W2061137826 @default.
• W2314798712 cites W2061194988 @default.
• W2314798712 cites W2062362165 @default.
• W2314798712 cites W2067756304 @default.
• W2314798712 cites W2072031052 @default.
• W2314798712 cites W2075948224 @default.
• W2314798712 cites W2077600747 @default.
• W2314798712 cites W2077803988 @default.
• W2314798712 cites W2082350511 @default.
• W2314798712 cites W2082396725 @default.
• W2314798712 cites W2082544020 @default.
• W2314798712 cites W2083173530 @default.
• W2314798712 cites W2086223988 @default.
• W2314798712 cites W2089181496 @default.
• W2314798712 cites W2090369174 @default.
• W2314798712 cites W2090785276 @default.
• W2314798712 cites W2101473785 @default.
• W2314798712 cites W2101577939 @default.
• W2314798712 cites W2102467528 @default.
• W2314798712 cites W2106310909 @default.
• W2314798712 cites W2107293905 @default.
• W2314798712 cites W2108530765 @default.
• W2314798712 cites W2108616691 @default.
• W2314798712 cites W2109082343 @default.
• W2314798712 cites W2110054763 @default.
• W2314798712 cites W2110803731 @default.
• W2314798712 cites W2117064229 @default.
• W2314798712 cites W2118546214 @default.
• W2314798712 cites W2118603221 @default.
• W2314798712 cites W2120088134 @default.
• W2314798712 cites W2121555819 @default.
• W2314798712 cites W2121651180 @default.
• W2314798712 cites W2122816289 @default.
• W2314798712 cites W2123385290 @default.
• W2314798712 cites W2125231275 @default.
• W2314798712 cites W2127042507 @default.
• W2314798712 cites W2127253161 @default.
• W2314798712 cites W2129266432 @default.
• W2314798712 cites W2130186887 @default.
• W2314798712 cites W2130443164 @default.
• W2314798712 cites W2130478228 @default.
• W2314798712 cites W2131256712 @default.
• W2314798712 cites W2131824057 @default.
• W2314798712 cites W2132009596 @default.
• W2314798712 cites W2132491970 @default.
• W2314798712 cites W2137285136 @default.
• W2314798712 cites W2139620679 @default.
• W2314798712 cites W2140024196 @default.
• W2314798712 cites W2142351984 @default.
• W2314798712 cites W2142594778 @default.
• W2314798712 cites W2143601096 @default.

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