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• W2314831386 abstract "Copper ions play a crucial role in living systems as cofactors of numerous metalloenzymes. To quantitatively estimate the Cu2+ concentration in human tissue, we have developed a two-photon (TP) probe with an internal reference (ACCu2) that shows significant TP action cross-section and high selectivity for Cu2+ and can quantitatively estimate the Cu2+ concentration in human colon tissues by dual-color two-photon microscopy (TPM) imaging with minimum interference from other competing metal ions or pH and minimum cytotoxicity and photostability problems. The Cu2+ concentrations in human normal colon, polyp, and colon cancer tissues were found to be 8.3 ± 0.3, 13 ± 2, and 22 ± 3 μM, respectively. This result suggests that ACCu2 may be useful for the diagnosis of human colon cancer." @default.
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• W2314831386 date "2014-05-13" @default.
• W2314831386 modified "2023-09-25" @default.
• W2314831386 title "Two-Photon Probe for Cu²⁺ with an Internal Reference: Quantitative Estimation of Cu²⁺ in Human Tissues by Two-Photon Microscopy" @default.
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• W2314831386 doi "https://doi.org/10.1021/ac500329k" @default.
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• W2314831386 hasPublicationYear "2014" @default.
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