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• W2314848262 abstract "Phosphatidylinositol 3-kinases (PI3Ks) include members of a unique and conserved family of intracellular lipid kinases that phosphorylate the 3-hydroxyl group of phosphatidylino-sitols and phosphoinositides. The resultant activation of many intracellular signalling pathways regulates various biological functions such as cell metabolism, survival, growth, proliferation, polarity, and apoptosis. PI3Ks are classified into three types: class I, II, and III. Of them, class I PI3K is most widely studied and plays an important role in the development and progression of tumours. In this review, we describe PI3K family members and their functions, especially the subunits of class I PI3K, their alterations in cancers, as well as PI3K inhibitors and their clinical trial status in cancer-targeted therapy. Phosphatidylinositol 3-kinases (PI3Ks) include members of a unique and conserved family of intracellular lipid kinases that phosphorylate the 3-hydroxyl group of phosphatidylino-sitols and phosphoinositides. The resultant activation of many intracellular signalling pathways regulates various biological functions such as cell metabolism, survival, growth, proliferation, polarity, and apoptosis. PI3Ks are classified into three types: class I, II, and III. Of them, class I PI3K is most widely studied and plays an important role in the development and progression of tumours. In this review, we describe PI3K family members and their functions, especially the subunits of class I PI3K, their alterations in cancers, as well as PI3K inhibitors and their clinical trial status in cancer-targeted therapy." @default.
• W2314848262 created "2016-06-24" @default.
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• W2314848262 creator A5041088271 @default.
• W2314848262 creator A5074258529 @default.
• W2314848262 date "2014-04-01" @default.
• W2314848262 modified "2023-09-27" @default.
• W2314848262 title "Advances in subunits of PI3K class I in cancer" @default.
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• W2314848262 doi "https://doi.org/10.1097/pat.0000000000000066" @default.
• W2314848262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24614719" @default.
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