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- W2314872024 abstract "Coagulant cancer antigen 1 (CCA-1) is a protease which activates factor X. CCA-1 demonstrates cancer-specific expression on immunohistological staining of breast cancer cells with anti-CCA-1 monoclonal antibody, a specific inhibitor of the coagulant activity of CCA-1. In the present study, the intensity of cell surface expression of tissue factor (TF), one of the procoagulant activators arising from cancer, and CCA-1 was determined in human breast cancer-derived cells by flow cytometry using anti-TF antibody and anti-CCA-1 antibody, respectively, as the primary antibodies. The influence of cell-induced coagulant activity on the coagulation time of human normal plasma was analyzed further using the above-mentioned antibodies. As a result, CCA-1 expression was observed in 4 out of 6 cells at the high rate of 65-95%. The degree of anti-CCA-1 antibody-induced coagulant inhibition was observed to be proportional to the intensity of CCA-1 expression. The intensity of TF expression was low in all of the cells, being under the level of 13%. The cells with proven TF expression showed concentration-dependent coagulant inhibition with the addition of anti-TF antibody. Conventionally, TF has been regarded as a major factor underlying blood coagulation on the cell surface. The present study revealed that compared to TF, the intensity of expression and the degree of distribution of CCA-1 were greater on the surface of breast cancer cells. These findings suggested that CCA-1 also plays an important role in blood coagulation induced by breast cancer cells." @default.
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- W2314872024 date "1996-01-01" @default.
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- W2314872024 title "Roll of Tissue Factor and Coagulant Cancer Antigen 1 in the Procoagulant activity of breast Cancer Cell Lines" @default.
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