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• W2314893347 endingPage "1060" @default.
• W2314893347 startingPage "1052" @default.
• W2314893347 abstract "Salivary adenoid cystic carcinoma (SACC), which is one of the most common malignant tumors of the salivary glands, is associated with a poor long-term outcome. There are currently few therapeutic options for patients with SACC. Recent studies have shown the potential of the application of ultraviolet-C (UV-C) irradiation for the treatment of human cancer. In the present study, we investigated the effects of UV-C in the SACC cell lines SACC-83 and SACC-LM. High-dose UV-C (200 J/m2) induced apoptosis and inhibited colony formation significantly. However, low-dose UV-C (10 J/m2), which had little effect on apoptosis and colony formation, increased the ability of migration in SACC cells accompanied by a decrease in E-cadherin and an increase in vimentin, suggesting the occurrence of epithelial–mesenchymal transition (EMT). Low-dose UV-C (10 J/m2) also resulted in upregulation of the phosphorylated forms of epidermal growth factor receptor (EGFR) and Akt (p-EGFR and p-Akt, respectively). Pretreatment with Nimotuzumab, an anti-EGFR monoclonal antibody, reversed the EMT as well as upregulation of p-EGFR/p-Akt induced by UV-C. Moreover, Nimotuzumab enhanced UV-C induced apoptosis and inhibition of colony formation. Our results indicate that EMT exerts a protective effect against apoptosis induced by low-dose UV-C. Thus, the combined application of Nimotuzumab and low-dose UV-C in vitro has an advantageous antitumor effect in SACC compared with the application of UV-C alone." @default.
• W2314893347 created "2016-06-24" @default.
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• W2314893347 date "2014-10-01" @default.
• W2314893347 modified "2023-09-26" @default.
• W2314893347 title "Nimotuzumab suppresses epithelial–mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro" @default.
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• W2314893347 doi "https://doi.org/10.1097/cad.0000000000000139" @default.
• W2314893347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25035960" @default.
• W2314893347 hasPublicationYear "2014" @default.
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