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- W2314893535 abstract "Objective Metamizol, probably with its vascular smooth muscle relaxant effect, enhances rest myocardial perfusion with the use of technetium-99m-methoxyisobutylisonitrile. We aimed to investigate whether metamizol induction is also able to increase the detectability of the ischemic/jeopardized myocardium during thallium-201 myocardial perfusion scintigraphy (MPS). Methods Twenty patients who had partially reversible/irreversible perfusion defects on their routine stress–redistribution–reinjection thallium-201 MPS were enrolled and metamizol-induced thallium-201 MPS (111 MBq thallium-201 was injected 45 min after 1 g oral metamizol) was acquired (10 min, 1 and 3 h later). Routine MPS and metamizol-induced MPS images were interpreted on the model of 17 segments using a visual uptake score (VUS; 0=normal, 1=mild, 2=moderate, 3=significant decreases, 4=no uptake). Thallium-201 uptake ratios (mean counts in the region of the perfusion defect/mean counts in the region of the normal-perfused wall) were calculated for each MPS. Blood pressure was monitored at 15-min intervals. MPS were compared with coronary angiography results. Results Visual uptake score and thallium-201 uptake ratio results indicated that in the first and third hour metamizol-induced thallium-201 uptake was significantly higher (P<0.001) than the redistribution/reinjection studies in 26 ischemic myocardial walls. Fourteen myocardial walls showed no thallium-201 uptake on either MPS and were considered as myocardial infarction. Statistically significant but asymptomatic decreases in blood pressure were observed. Coronary angiography results were in concordance with metamizol-induced MPS. Conclusion Metamizol increases the detectability of ischemic/viable myocardium during MPS with thallium-201 and could be used with MPS." @default.
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- W2314893535 date "2011-02-01" @default.
- W2314893535 modified "2023-09-24" @default.
- W2314893535 title "The role of metamizol induction for the detection of perfusion reversibility on thallium-201 myocardial perfusion scintigraphy" @default.
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- W2314893535 doi "https://doi.org/10.1097/mnm.0b013e3283413041" @default.
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