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• W2314894449 abstract "Abnormal substantia nigra morphology in heal- thy individuals, viewed with transcranial ultrasound, is a significant risk factor for Parkinson's disease. However, little is known about the functional consequences of this abnor- mality (termed 'hyperechogenicity') on movement. The aim of the current study was to investigate hand function in healthy older adults with (SN?) and without (SN- )s ub- stantia nigra hyperechogenicity during object manipulation. We hypothesised that SN? subjects would exhibit increased grip force and a slower rate of force application compared to SN- subjects. Twenty-six healthy older adults (8 SN? aged 58 ± 8y ears, 18 SN- aged 57 ± 6y ears) were asked to grip and lift a light-weight object with the dominant hand. Horizontal grip force, vertical lift force, acceleration, and first dorsal interosseus EMG were recorded during three trials. During the first trial, SN? subjects exhibited a longer period between grip onset and lift onset (i.e. preload duration; 0.27 ± 0.25 s) than SN- subjects (0.13 ± 0.08 s; P = 0.046). They also exerted a greater downward force prior to lift off (-0.54 ± 0.42 N vs. -0.21 ± 0.12 N; P = 0.005) and used a greater grip force to lift the object (19.5 ± 7.0 N vs. 14.0 ± 4.3 N; P = 0.022) than SN- subjects. No between group differences were observed in subsequent trials. SN? subjects exhibit impaired planning for manipulation of new objects. SN? individuals over- estimate the grip force required, despite a longer contact period prior to lifting the object. The pattern of impairment observed in SN? subjects shares similarities with de novo Parkinson's disease patients." @default.
• W2314894449 created "2016-06-24" @default.
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• W2314894449 date "2014-01-01" @default.
• W2314894449 modified "2023-09-24" @default.
• W2314894449 title "Hand function is impaired in healthy older adults at risk of Parkinson's disease" @default.
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