FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314921844> ?p ?o ?g. }

• W2314921844 endingPage "3024" @default.
• W2314921844 startingPage "3024" @default.
• W2314921844 abstract "Abstract Introduction Stimulation of Fibroblast-growth-factor-receptor-1 (FGFR1) plays an important role in cell differentiation and cell growth. Amplification of the FGFR1 gene was described in various cancer types. Clinical phase I trials are currently performed to address the potential applicability of anti-FGFR1-drugs in squamous cell carcinoma of the lung. Prevalence and clinical significance of FGFR1 amplification are unknown in esophageal carcinoma. Material and Methods In this study, six hundred formalin-fixed paraffin-embedded tissue samples from patients with esophageal carcinoma were analysed, including 346 patients with adenocarcinoma and 254 patients with squamous cell carcinoma. Dual-labeling Fluorescence in situ hybridization (FISH) was applied using probes for FGFR1 and centromere 8. The initial analysis was in a tissue microarray (TMA) format. All available tumor blocks from amplified tumors were subsequently analysed for heterogeneity on large sections. When available, lymph node metastases and tumor-adjacent dysplasia were also analysed on large sections from these tumors, Results FGFR1 amplification was more frequently seen in squamous cell carcinoma (9.4% of 202 interpretable cases) than in adenocarcinoma (1.6% of 308). High polysomy was found in an additional 5.9% of squamous cell carcinoma and 0.6% of adenocarcinoma. FGFR1 amplification was significantly associated with histologic grade (p=0.02) but was unrelated to tumor type, pT, pN, pM, UICC stage and survival. FGFR1 amplification was homogeneous across the tumor in most cases. FGFR1 heterogeneity was observed in only 3 of 24 cases. FGFR1 amplification was similarly observed in the primary tumor and in 6 cases each of lymph node metastases and dysplasia. Summary In conclusion, FGFR1 amplification in squamous cell carcinoma of the esophagus occurs at similar frequencies as in squamous cell carcinoma of the lung. The high homogeneity of FGFR1 in the primary tumor and the lack of discordant results in dysplasia argue for FGFR1 amplification, representing an early alteration in a subgroup of esophageal cancers. The high homogeneity of FGFR1 amplification provides further arguments for FGFR1 representing an interesting drug target in these cancers. Citation Format: Katharina von Loga, Jule Kohlhaussen, Andreas H. Marx, Guido Sauter, Tobias Grob, Alexander Quaas. FGFR1 amplification is linked to the squamous cell carcinoma subtype in esophageal carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3024. doi:10.1158/1538-7445.AM2013-3024" @default.
• W2314921844 created "2016-06-24" @default.
• W2314921844 creator A5017679388 @default.
• W2314921844 creator A5021421424 @default.
• W2314921844 creator A5035525469 @default.
• W2314921844 creator A5041533638 @default.
• W2314921844 creator A5045953059 @default.
• W2314921844 creator A5063249127 @default.
• W2314921844 date "2013-04-01" @default.
• W2314921844 modified "2023-09-26" @default.
• W2314921844 title "Abstract 3024: FGFR1 amplification is linked to the squamous cell carcinoma subtype in esophageal carcinoma." @default.
• W2314921844 doi "https://doi.org/10.1158/1538-7445.am2013-3024" @default.
• W2314921844 hasPublicationYear "2013" @default.
• W2314921844 type Work @default.
• W2314921844 sameAs 2314921844 @default.
• W2314921844 citedByCount "4" @default.
• W2314921844 countsByYear W23149218442015 @default.
• W2314921844 countsByYear W23149218442017 @default.
• W2314921844 countsByYear W23149218442018 @default.
• W2314921844 crossrefType "journal-article" @default.
• W2314921844 hasAuthorship W2314921844A5017679388 @default.
• W2314921844 hasAuthorship W2314921844A5021421424 @default.
• W2314921844 hasAuthorship W2314921844A5035525469 @default.
• W2314921844 hasAuthorship W2314921844A5041533638 @default.
• W2314921844 hasAuthorship W2314921844A5045953059 @default.
• W2314921844 hasAuthorship W2314921844A5063249127 @default.
• W2314921844 hasConcept C104317684 @default.
• W2314921844 hasConcept C121608353 @default.
• W2314921844 hasConcept C126322002 @default.
• W2314921844 hasConcept C142724271 @default.
• W2314921844 hasConcept C143998085 @default.
• W2314921844 hasConcept C170493617 @default.
• W2314921844 hasConcept C193270364 @default.
• W2314921844 hasConcept C2777542201 @default.
• W2314921844 hasConcept C2777546739 @default.
• W2314921844 hasConcept C2781182431 @default.
• W2314921844 hasConcept C2781303241 @default.
• W2314921844 hasConcept C2994491419 @default.
• W2314921844 hasConcept C30481170 @default.
• W2314921844 hasConcept C49418065 @default.
• W2314921844 hasConcept C502942594 @default.
• W2314921844 hasConcept C55493867 @default.
• W2314921844 hasConcept C71924100 @default.
• W2314921844 hasConcept C74373430 @default.
• W2314921844 hasConcept C86803240 @default.
• W2314921844 hasConceptScore W2314921844C104317684 @default.
• W2314921844 hasConceptScore W2314921844C121608353 @default.
• W2314921844 hasConceptScore W2314921844C126322002 @default.
• W2314921844 hasConceptScore W2314921844C142724271 @default.
• W2314921844 hasConceptScore W2314921844C143998085 @default.
• W2314921844 hasConceptScore W2314921844C170493617 @default.
• W2314921844 hasConceptScore W2314921844C193270364 @default.
• W2314921844 hasConceptScore W2314921844C2777542201 @default.
• W2314921844 hasConceptScore W2314921844C2777546739 @default.
• W2314921844 hasConceptScore W2314921844C2781182431 @default.
• W2314921844 hasConceptScore W2314921844C2781303241 @default.
• W2314921844 hasConceptScore W2314921844C2994491419 @default.
• W2314921844 hasConceptScore W2314921844C30481170 @default.
• W2314921844 hasConceptScore W2314921844C49418065 @default.
• W2314921844 hasConceptScore W2314921844C502942594 @default.
• W2314921844 hasConceptScore W2314921844C55493867 @default.
• W2314921844 hasConceptScore W2314921844C71924100 @default.
• W2314921844 hasConceptScore W2314921844C74373430 @default.
• W2314921844 hasConceptScore W2314921844C86803240 @default.
• W2314921844 hasIssue "8_Supplement" @default.
• W2314921844 hasLocation W23149218441 @default.
• W2314921844 hasOpenAccess W2314921844 @default.
• W2314921844 hasPrimaryLocation W23149218441 @default.
• W2314921844 hasRelatedWork W1855101007 @default.
• W2314921844 hasRelatedWork W1991461208 @default.
• W2314921844 hasRelatedWork W2004950991 @default.
• W2314921844 hasRelatedWork W2006879360 @default.
• W2314921844 hasRelatedWork W2029410776 @default.
• W2314921844 hasRelatedWork W2155324615 @default.
• W2314921844 hasRelatedWork W2314921844 @default.
• W2314921844 hasRelatedWork W2567331406 @default.
• W2314921844 hasRelatedWork W2598672226 @default.
• W2314921844 hasRelatedWork W3140712098 @default.
• W2314921844 hasVolume "73" @default.
• W2314921844 isParatext "false" @default.
• W2314921844 isRetracted "false" @default.
• W2314921844 magId "2314921844" @default.
• W2314921844 workType "article" @default.