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- W2314929087 abstract "In mammals, T and B lymphocytes develop from precursor pluripotent stem cells along separate lineages. As they differentiate, they express lineage as well as differentiation stage-specific surface markers. T and B cells recognize antigen via T-cell receptor (TCR) or immunoglobulin (Ig) molecules, respectively. Both of these consist of two distinct polypeptide chains, which in turn contain variable (V) and constant (C) domains. The genes encoding the V and C domains are separate and occur in clusters in the germ line. During differentiation, the rearrangement and juxtaposition of two or three of such genetic elements results in the expression of functional mRNA for individual polypeptides. Although a large number of gene segments encoding V, diversity (D), and joining (J) region of the polypeptides are available in the germ line for each polypeptide, only one functional immunoglobulin or TCR molecule is synthesized in a lymphocyte. This leads to diversity in the lymphocyte..." @default.
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- W2314929087 date "1989-01-01" @default.
- W2314929087 modified "2023-09-26" @default.
- W2314929087 title "The Role of Idiotypic Interactions and B-cell Subsets in Development of the B-cell Repertoire" @default.
- W2314929087 doi "https://doi.org/10.1101/sqb.1989.054.01.025" @default.
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