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- W2314933178 abstract "Mucosal specimens obtained from the upper aerodigestive tract of 101 patients were assayed for prostaglandin E 2 (PGE 2 ). Prostaglandin was detected in all specimens evaluated. Children and nonsmoking adults demonstrated lower concentrations of PGE 2 than smoking adults. Tumor specimens from patients with squamous cell carcinoma of the upper aerodigestive tract demonstrated significantly increased levels of PGE 2 (P<.05). Normal mucosa obtained from patients with squamous carcinoma elsewhere in their upper aerodigestive tract was found to contain significantly more PGE 2 than that from adults without tumors (P<.05). The amount of PGE 2 released from a tissue biopsy was not related to the amount of mononuclear cell infiltrate. No age-related trends in PGE 2 levels were noted. Prostaglandin levels were higher in patients with advanced tumors in comparison to smaller tumors. The possible impact of elevated levels of PGE 2 upon the immune system, the subsequent development of second primary carcinomas, and the relationship between PGE 2 and the use of tobacco products is discussed." @default.
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- W2314933178 date "1987-03-01" @default.
- W2314933178 modified "2023-09-27" @default.
- W2314933178 title "Prostaglandin E2 of the Upper Aerodigestive Tract" @default.
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- W2314933178 doi "https://doi.org/10.1177/000348948709600215" @default.
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