FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314950916> ?p ?o ?g. }

• W2314950916 abstract "Background: Population-based mammography screening has resulted in the increased detection of suspicious, non-palpable lesions that require histopathological assessment. When a “pre-malignant” lesion, such as lobular carcinoma in situ (LCIS), atypical ductal or lobular hyperplasia (ADH and ALH) or flat epithelial atypia (FEA), is discovered on the primary biopsy, a surgical excision is recommended due to the risk of underestimation of the lesion. DCIS or invasive carcinoma is finally retrieved in 10–30% of the patients, meaning a large part receive unnecessary surgery. The aim of this study was to define a nomogram integrating clinical, imaging and histological data to predict for the risk of underestimation of the lesion. Intentionally, we decided to include all the premalignant lesions which implied the same management, whereas most of the previous models of the literature are focused in only one or another type of atypia. Patients and Methods: We collected complete clinical, radiological and double-reading histological data on all patients with a diagnosis of pure atypical lesion (CLIS, ADH, ALH, FEA) on image-guided biopsy performed at the One-Stop Unjt of our breast care center from 2004 to 2011. Univariate and multivariate logistic regression analyses were used to develop a model predicting for the presence of DCIS or invasive carcinoma on the final surgical sample, and build a nomogram. This nomogram was evaluated on a training set of 205 patients treated at IGR. Results: 205 patients were eligible for the study. Of these 205 patients, 50 cancers (24.4%) were diagnosed at definitive surgery (21 DCIS, 20 ductal and 9 lobular invasive carcinoma). Univariate analysis retrieved age (p = 0.03), number of biopsy cores (p = 0.02) and type of radiological anomalies (p = 0.02) as factors associated with cancer at surgery. The presence of microcalcifications on biopsies of limit significance was included in the multivariate analysis (p = 0.09). The final most informative nomogram included information on patient age (p = 0.03), type of radiological anomalies (p = 0.02) and number of biopsy cores (p = 0.04). The predictive accuracy of the nomogram was 0.71 and 0.68 in the training set before and after bootstrapping, respectively. The calibration of the nomogram was good. The sensitivity, specificity, positive predictive value, and negative predictive values were 68%, 73%, 45%, and 88%, respectively. Conclusion: This nomogram could help identify a subset of patients with premalignant disease for whom surgery could be spared and who would be eligible for exclusive clinical follow-up. A validation study is currently undergoing in an external dataset. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-12-01." @default.
• W2314950916 created "2016-06-24" @default.
• W2314950916 creator A5003451312 @default.
• W2314950916 creator A5012791762 @default.
• W2314950916 creator A5025883323 @default.
• W2314950916 creator A5049746519 @default.
• W2314950916 creator A5050333038 @default.
• W2314950916 creator A5083142899 @default.
• W2314950916 date "2012-12-15" @default.
• W2314950916 modified "2023-09-30" @default.
• W2314950916 title "Abstract P4-12-01: A nomogram based on clinical, imaging and histological data to predict the risk of upgrades to malignancy at surgery in biopsy-diagnosed premalignant lesions of the breast" @default.
• W2314950916 doi "https://doi.org/10.1158/0008-5472.sabcs12-p4-12-01" @default.
• W2314950916 hasPublicationYear "2012" @default.
• W2314950916 type Work @default.
• W2314950916 sameAs 2314950916 @default.
• W2314950916 citedByCount "0" @default.
• W2314950916 crossrefType "proceedings-article" @default.
• W2314950916 hasAuthorship W2314950916A5003451312 @default.
• W2314950916 hasAuthorship W2314950916A5012791762 @default.
• W2314950916 hasAuthorship W2314950916A5025883323 @default.
• W2314950916 hasAuthorship W2314950916A5049746519 @default.
• W2314950916 hasAuthorship W2314950916A5050333038 @default.
• W2314950916 hasAuthorship W2314950916A5083142899 @default.
• W2314950916 hasConcept C121608353 @default.
• W2314950916 hasConcept C126322002 @default.
• W2314950916 hasConcept C126838900 @default.
• W2314950916 hasConcept C141071460 @default.
• W2314950916 hasConcept C142724271 @default.
• W2314950916 hasConcept C143998085 @default.
• W2314950916 hasConcept C2775904963 @default.
• W2314950916 hasConcept C2775934546 @default.
• W2314950916 hasConcept C2777517664 @default.
• W2314950916 hasConcept C2777546739 @default.
• W2314950916 hasConcept C2779296616 @default.
• W2314950916 hasConcept C2779399171 @default.
• W2314950916 hasConcept C2780472235 @default.
• W2314950916 hasConcept C2780862961 @default.
• W2314950916 hasConcept C2781156865 @default.
• W2314950916 hasConcept C2781283455 @default.
• W2314950916 hasConcept C2908647359 @default.
• W2314950916 hasConcept C34626388 @default.
• W2314950916 hasConcept C530470458 @default.
• W2314950916 hasConcept C71924100 @default.
• W2314950916 hasConcept C99454951 @default.
• W2314950916 hasConceptScore W2314950916C121608353 @default.
• W2314950916 hasConceptScore W2314950916C126322002 @default.
• W2314950916 hasConceptScore W2314950916C126838900 @default.
• W2314950916 hasConceptScore W2314950916C141071460 @default.
• W2314950916 hasConceptScore W2314950916C142724271 @default.
• W2314950916 hasConceptScore W2314950916C143998085 @default.
• W2314950916 hasConceptScore W2314950916C2775904963 @default.
• W2314950916 hasConceptScore W2314950916C2775934546 @default.
• W2314950916 hasConceptScore W2314950916C2777517664 @default.
• W2314950916 hasConceptScore W2314950916C2777546739 @default.
• W2314950916 hasConceptScore W2314950916C2779296616 @default.
• W2314950916 hasConceptScore W2314950916C2779399171 @default.
• W2314950916 hasConceptScore W2314950916C2780472235 @default.
• W2314950916 hasConceptScore W2314950916C2780862961 @default.
• W2314950916 hasConceptScore W2314950916C2781156865 @default.
• W2314950916 hasConceptScore W2314950916C2781283455 @default.
• W2314950916 hasConceptScore W2314950916C2908647359 @default.
• W2314950916 hasConceptScore W2314950916C34626388 @default.
• W2314950916 hasConceptScore W2314950916C530470458 @default.
• W2314950916 hasConceptScore W2314950916C71924100 @default.
• W2314950916 hasConceptScore W2314950916C99454951 @default.
• W2314950916 hasLocation W23149509161 @default.
• W2314950916 hasOpenAccess W2314950916 @default.
• W2314950916 hasPrimaryLocation W23149509161 @default.
• W2314950916 hasRelatedWork W1483867148 @default.
• W2314950916 hasRelatedWork W1887287895 @default.
• W2314950916 hasRelatedWork W196197791 @default.
• W2314950916 hasRelatedWork W1986265397 @default.
• W2314950916 hasRelatedWork W2124915004 @default.
• W2314950916 hasRelatedWork W2133826633 @default.
• W2314950916 hasRelatedWork W2135585327 @default.
• W2314950916 hasRelatedWork W2313806937 @default.
• W2314950916 hasRelatedWork W2317185886 @default.
• W2314950916 hasRelatedWork W2509104826 @default.
• W2314950916 hasRelatedWork W2605568489 @default.
• W2314950916 hasRelatedWork W2746298461 @default.
• W2314950916 hasRelatedWork W2897036123 @default.
• W2314950916 hasRelatedWork W2909691544 @default.
• W2314950916 hasRelatedWork W2979231788 @default.
• W2314950916 hasRelatedWork W3001322414 @default.
• W2314950916 hasRelatedWork W3044273481 @default.
• W2314950916 hasRelatedWork W3091148781 @default.
• W2314950916 hasRelatedWork W3175145497 @default.
• W2314950916 hasRelatedWork W2106011225 @default.
• W2314950916 isParatext "false" @default.
• W2314950916 isRetracted "false" @default.
• W2314950916 magId "2314950916" @default.
• W2314950916 workType "article" @default.