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- W2314964327 abstract "A series of thioxanthenes was tested for cytotoxicity to isolated rat hepatocytes, as measured by the loss of an intracellular enzyme (GOT) to the surrounding medium. The relative order of potency was found to be: SKF 10812 > cis. = trans-chlorprothixene = N-756A > cis- = trans-flupenthixol > xanthiol > methixene = cis- = trans-clopenthixol = N-716 > N-710. The presence of an unsaturated exocyclic bond increased the apparent toxicity as did the presence of a substituent (trifluoromethyl, chlorine, bromine) at the two position of the tricyclic nucleus. The trifluoromethyl substituted thioxanthenes were three to four times more potent than their halogenated analogs, but there were no differences in potency among the halogenated (chlorine or bromine) thioxanthenes. Compounds which had a dimethylaminopropylidene side chain were five to six times stronger in causing enzyme leakage than were their analog which had a hydroxyethylpipera-zinylpropylidene side cain. Although only the cis-isomers of each compound are highly active neuroleptics, both isomers were equipotent at causing the efflux of GOT from rat hepatocytes." @default.
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- W2314964327 date "1975-11-01" @default.
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- W2314964327 title "The Toxicity of Thioxanthene Neuroleptics to Isolated Rat Liver Cells" @default.
- W2314964327 doi "https://doi.org/10.3181/00379727-150-39041" @default.
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