FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314973436> ?p ?o ?g. }

• W2314973436 endingPage "44" @default.
• W2314973436 startingPage "39" @default.
• W2314973436 abstract "Lithium and valproate are chemically unrelated compounds that are used to treat manic-depressive illness. Previously, we reported that lithium ions upregulate genes encoding proteins primarily associated with large dense core vesicles (LDCV) in nerve growth factor (NGF)-differentiated PC12 cells, but not in undifferentiated PC12 cells. Moreover, lithium did not alter the expression of proteins associated with small-clear, synaptic-like vesicles (SSV) in these cells. Based on these observations, we investigated whether valproate had actions similar to those of lithium in PC12 cells. Thus, undifferentiated or NGF-differentiated PC12 cells were exposed to lithium (1 mM) or valproate (1 mM) for 48 h. Extracts from these cells were submitted to semiquantitative Northern and Western analyses. In NGF-differentiated cells, both agents increased the expression of proteins associated with LDCV, the vesicular monoamine transporter 1 (VMAT1), and cysteine string protein (CSP). These same treatments did not alter the expression of proteins primarily associated with SSV, the vesicular acetylcholine transporter (VAChT), and synaptophysin (SY). Furthermore, neither drug affected the expression of these proteins in undifferentiated cells. Interestingly, secretion of (3)H-dopamine was increased in cells exhibiting the increase of VMAT1 and csp. Taken together, the convergent effects of these chemically diverse compounds suggest that altered dynamics of LDCV may play a vital role in the biochemical pathway, leading to the relief of the symptoms of manic depression." @default.
• W2314973436 created "2016-06-24" @default.
• W2314973436 creator A5004918292 @default.
• W2314973436 creator A5037127181 @default.
• W2314973436 creator A5040201398 @default.
• W2314973436 date "2003-09-03" @default.
• W2314973436 modified "2023-10-16" @default.
• W2314973436 title "Convergent Effects of Lithium and Valproate on the Expression of Proteins Associated with Large Dense Core Vesicles in NGF-differentiated PC12 Cells" @default.
• W2314973436 cites W1964684267 @default.
• W2314973436 cites W1965374740 @default.
• W2314973436 cites W1974585730 @default.
• W2314973436 cites W1981812461 @default.
• W2314973436 cites W1991408596 @default.
• W2314973436 cites W1996231894 @default.
• W2314973436 cites W1998137325 @default.
• W2314973436 cites W2004630050 @default.
• W2314973436 cites W2004851263 @default.
• W2314973436 cites W2006427869 @default.
• W2314973436 cites W2006986579 @default.
• W2314973436 cites W2013307620 @default.
• W2314973436 cites W2014860907 @default.
• W2314973436 cites W2021181413 @default.
• W2314973436 cites W2026155519 @default.
• W2314973436 cites W2029305411 @default.
• W2314973436 cites W2031735194 @default.
• W2314973436 cites W2031888868 @default.
• W2314973436 cites W2034561104 @default.
• W2314973436 cites W2036203988 @default.
• W2314973436 cites W2038689311 @default.
• W2314973436 cites W2039559232 @default.
• W2314973436 cites W2040554596 @default.
• W2314973436 cites W2040793114 @default.
• W2314973436 cites W2047177765 @default.
• W2314973436 cites W2052462097 @default.
• W2314973436 cites W2071378588 @default.
• W2314973436 cites W2076403167 @default.
• W2314973436 cites W2080669192 @default.
• W2314973436 cites W2083942007 @default.
• W2314973436 cites W2087178211 @default.
• W2314973436 cites W2094167557 @default.
• W2314973436 cites W2094737649 @default.
• W2314973436 cites W2129969030 @default.
• W2314973436 cites W2149532780 @default.
• W2314973436 cites W4293247451 @default.
• W2314973436 doi "https://doi.org/10.1038/sj.npp.1300288" @default.
• W2314973436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12955095" @default.
• W2314973436 hasPublicationYear "2003" @default.
• W2314973436 type Work @default.
• W2314973436 sameAs 2314973436 @default.
• W2314973436 citedByCount "30" @default.
• W2314973436 countsByYear W23149734362012 @default.
• W2314973436 countsByYear W23149734362013 @default.
• W2314973436 countsByYear W23149734362017 @default.
• W2314973436 countsByYear W23149734362019 @default.
• W2314973436 countsByYear W23149734362022 @default.
• W2314973436 countsByYear W23149734362023 @default.
• W2314973436 crossrefType "journal-article" @default.
• W2314973436 hasAuthorship W2314973436A5004918292 @default.
• W2314973436 hasAuthorship W2314973436A5037127181 @default.
• W2314973436 hasAuthorship W2314973436A5040201398 @default.
• W2314973436 hasBestOaLocation W23149734361 @default.
• W2314973436 hasConcept C126322002 @default.
• W2314973436 hasConcept C134018914 @default.
• W2314973436 hasConcept C170493617 @default.
• W2314973436 hasConcept C185592680 @default.
• W2314973436 hasConcept C187714386 @default.
• W2314973436 hasConcept C203014093 @default.
• W2314973436 hasConcept C204232928 @default.
• W2314973436 hasConcept C2775864247 @default.
• W2314973436 hasConcept C2777209535 @default.
• W2314973436 hasConcept C2778423431 @default.
• W2314973436 hasConcept C2778541603 @default.
• W2314973436 hasConcept C55493867 @default.
• W2314973436 hasConcept C71924100 @default.
• W2314973436 hasConcept C86803240 @default.
• W2314973436 hasConcept C95444343 @default.
• W2314973436 hasConceptScore W2314973436C126322002 @default.
• W2314973436 hasConceptScore W2314973436C134018914 @default.
• W2314973436 hasConceptScore W2314973436C170493617 @default.
• W2314973436 hasConceptScore W2314973436C185592680 @default.
• W2314973436 hasConceptScore W2314973436C187714386 @default.
• W2314973436 hasConceptScore W2314973436C203014093 @default.
• W2314973436 hasConceptScore W2314973436C204232928 @default.
• W2314973436 hasConceptScore W2314973436C2775864247 @default.
• W2314973436 hasConceptScore W2314973436C2777209535 @default.
• W2314973436 hasConceptScore W2314973436C2778423431 @default.
• W2314973436 hasConceptScore W2314973436C2778541603 @default.
• W2314973436 hasConceptScore W2314973436C55493867 @default.
• W2314973436 hasConceptScore W2314973436C71924100 @default.
• W2314973436 hasConceptScore W2314973436C86803240 @default.
• W2314973436 hasConceptScore W2314973436C95444343 @default.
• W2314973436 hasIssue "1" @default.
• W2314973436 hasLocation W23149734361 @default.
• W2314973436 hasLocation W23149734362 @default.
• W2314973436 hasOpenAccess W2314973436 @default.
• W2314973436 hasPrimaryLocation W23149734361 @default.
• W2314973436 hasRelatedWork W1970563837 @default.
• W2314973436 hasRelatedWork W1993179896 @default.

• next