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- W2314984911 abstract "Introduction: Little data exists comparing the efficacy and safety of sedatives used in the post-operative period for patients newly implanted with left ventricular assist devices (LVAD). Methods: A retrospective chart review of adult patients who underwent a LVAD implantation and were admitted to St. Vincent Hospital's cardiothoracic vascular transplant unit (CVTU) was conducted from October 1st, 2010 to September 30, 2012. Patients were included with ≤30 days of MV and excluded if a continuous infusion of a benzodiazepine was utilized. Study consisted of two groups; a control group who did not receive DEX during their hospitalization and a study group who did receive DEX. Sedative and vasoactive agent use was collected from electronic medical records while demographics and secondary outcomes were primarily collected from financial charge data. End points assessed included ICU and hospital length of stay (LOS), duration of MV, ventilator-free days, reintubation rates, tracheostomy placement, duration and dose of vasoactive and inotrope agents, use of rescue medications, treatment of delirium, discharge status, and daily actual variable direct costs of the hospitalization. Results: Patients who received DEX had fewer MV days (median 2 days [IQR 2]) compared to the control group (median 3 days [IQR 4]; p=0.04). Neither ventilator-free days nor duration of inotrope and vasoactive agents differed significantly. Secondary outcomes did not differ except more patients who received DEX (90%) were discharged home compared to those on propofol alone (66%; p=0.04). Conclusions: DEX may be a more appropriate sedative choice in LVAD patients due to fewer MV days and no difference in costs. Health care organizations may realize cost-savings and patients benefit from improved quality of life with more patients discharged home who received DEX. We recommend further prospective research to determine if other outcomes may significantly differ between propofol and DEX." @default.
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- W2314984911 date "2013-12-01" @default.
- W2314984911 modified "2023-09-24" @default.
- W2314984911 title "866" @default.
- W2314984911 doi "https://doi.org/10.1097/01.ccm.0000440104.19255.99" @default.
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