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- W2314995655 abstract "Mechanically activated transducer channels in cochlear outer hair cells (OHC's) transduce sound encoded mechanical signals into electrical signals. Entry of extracellular Ca2+ through these channels modulates transduction by reducing their open probability, a phenomenon called adaptation [1]. Analysis of the mechanical and electrical characteristics of the transducer channels in OHC's has shown that the transducer channel's open probability can be adequately described by a differentially activating two-state model [2]. Also a direct relationship was demonstrated between the gating spring stiffness (K-s) and the accuracy (sigma(min) = 2kT/[K-s D] = 5.4 nm, where D is the distance between the engaging positions of the closed and open conformational state) with which hair bundle position can be detected as a result of intrinsic channel stochastics. In combination with an assumed Ca2+-dependent gating spring stiffness [e.g. 3], we predict on the basis of the two-state model that at endolymphatic Ca2+ concentrations (similar to 20 mu M) an improved accuracy (alpha(min) similar to 3 nm) can be attained at the equilibrium position of the hair bundle." @default.
- W2314995655 created "2016-06-24" @default.
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- W2314995655 date "2006-08-01" @default.
- W2314995655 modified "2023-09-25" @default.
- W2314995655 title "HAIR CELL TRANSDUCER CHANNEL PROPERTIES AND ACCURACY OF COCHLEAR SIGNAL-PROCESSING" @default.
- W2314995655 doi "https://doi.org/10.1142/9789812773456_0049" @default.
- W2314995655 hasPublicationYear "2006" @default.
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