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• W2314998889 abstract "Vanadium (V) is an air pollutant released into the atmosphere by burning fossil fuels. Also, it has been recently evaluated for their carcinogenic potential to establish permissible limits of exposure at workplaces. We previously reported an increase in the number and size of platelets and their precursor cells and megakaryocytes in bone marrow and spleen. The aim of this study was to identify the involvement of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway and thrombopoietin (TPO) receptor, and myeloproliferative leukemia virus oncogene (Mpl), in megakaryocyte proliferation induced by this compound. Mice were exposed twice a week to vanadium pentoxide inhalation (0.02 M) and were killed at 4th, 6th, and 8th week of exposure. Phosphorylated JAK2 (JAK2 ph), STAT3 (STAT3 ph), STAT5, and Mpl were identified in mice spleen megakaryocytes by cytofluorometry and immunohistochemistry. An increase in JAK2 ph and STAT3 ph, but a decrease in Mpl at 8-week exposure was identified in our findings. Taking together, we propose that the morphological findings, JAK/STAT activation, and decreased Mpl receptor induced by V leads to a condition comparable to essential thrombocythemia, so the effect on megakaryocytes caused by different mechanisms is similar. We also suggest that the decrease in Mpl is a negative feedback mechanism after the JAK/STAT activation. Since megakaryocytes are platelet precursors, their alteration affects platelet morphology and function, which might have implications in hemostasis as demonstrated previously, so it is important to continue evaluating the effects of toxics and pollutants on megakaryocytes and platelets." @default.
• W2314998889 created "2016-06-24" @default.
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• W2314998889 date "2014-01-17" @default.
• W2314998889 modified "2023-10-02" @default.
• W2314998889 title "Activation of Janus kinase/signal transducers and activators of transcription pathway involved in megakaryocyte proliferation induced by vanadium resembles some aspects of essential thrombocythemia" @default.
• W2314998889 cites W124910506 @default.
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• W2314998889 cites W181632829 @default.
• W2314998889 cites W1827885532 @default.
• W2314998889 cites W1944246793 @default.
• W2314998889 cites W1967959518 @default.
• W2314998889 cites W1970401962 @default.
• W2314998889 cites W1970493411 @default.
• W2314998889 cites W1972508213 @default.
• W2314998889 cites W1974901220 @default.
• W2314998889 cites W1981471739 @default.
• W2314998889 cites W1983819402 @default.
• W2314998889 cites W1990946341 @default.
• W2314998889 cites W1993961434 @default.
• W2314998889 cites W1999857898 @default.
• W2314998889 cites W2000428128 @default.
• W2314998889 cites W2007928677 @default.
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• W2314998889 cites W2013918511 @default.
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• W2314998889 cites W2034703335 @default.
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• W2314998889 cites W2082991655 @default.
• W2314998889 cites W2083701106 @default.
• W2314998889 cites W2083707526 @default.
• W2314998889 cites W2086661658 @default.
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• W2314998889 cites W2134923454 @default.
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• W2314998889 cites W2140665078 @default.
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• W2314998889 cites W2149844459 @default.
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• W2314998889 cites W29651041 @default.
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• W2314998889 doi "https://doi.org/10.1177/0748233713518600" @default.
• W2314998889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24442345" @default.
• W2314998889 hasPublicationYear "2014" @default.
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