Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315018631> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2315018631 abstract "Diffuse Large B-cell lymphoma (DLBCL), the most common type of lymphoma in adults, accounts for approximately 30 to 40% of newly diagnosed lymphomas. Using gene expression profiling, DLBCL can be divided into three immunologically indistinguishable subtypes: the germinal center B-cell like (GBC), the activated B-cell like (ABC) and the primary mediastinal B-cell lymphoma (PMBL) subtype. The aim of the study was to compare gene expression profiles of Swedish and Egyptian ABC DLBCL patients. Formalin fixed and paraffin embedded material of 67 Egyptian and 15 Swedish ABC DLBCL patients were used in the study. Affymetrix gene expression platform was used for profiling and the analysis was carried out using GeneSpring GX software. Quantitative PCR (qPCR) and confocal microscopy was used to verify the findings. The GeneSpring GX analysis showed that 3247 genes were at least 2 fold up- or downregulated comparing the two patient groups. Among these were 1827 genes upregulated and 1420 genes downregulated. Gene expression analysis was verified using qPCR showing that STAT3 was upregulated with a fold change of 3.1 in the Swedish patients and that STAT5b was upregulated with a fold change of 1.3 in the Egyptian patients. Confocal microscopy showed protein activity of STAT3 and 5b in the nucleus of Swedish and Egyptian patients respectively using monoclonal antibodies. This is the first study that reveals diversity in expression of STATs in different populations of ABC DLBCL patients. STAT3 and 5b are known to have different pathways of activation and targeted disruption has shown their functional differences. Using gene expression profiling, we revealed different expression levels of STAT3 and STAT5b in Swedish and Egyptian ABC DLBCL patients. Since the populations of Sweden and Egypt are exposed to different infectious agents, the results of the present study further raise the question concerning viral etiology in ABC-DLBCL possibly due to repeated infections and chronic inflammation. In general, these findings give additional evidence to the importance of signaling pathways involving STATs in ABC DLBCL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5011. doi:10.1158/1538-7445.AM2011-5011" @default.
- W2315018631 created "2016-06-24" @default.
- W2315018631 creator A5016320447 @default.
- W2315018631 creator A5019887534 @default.
- W2315018631 creator A5023600276 @default.
- W2315018631 creator A5030055287 @default.
- W2315018631 creator A5032924794 @default.
- W2315018631 creator A5038538552 @default.
- W2315018631 creator A5040702936 @default.
- W2315018631 creator A5069881022 @default.
- W2315018631 creator A5071309680 @default.
- W2315018631 date "2011-04-15" @default.
- W2315018631 modified "2023-10-18" @default.
- W2315018631 title "Abstract 5011: Difference in expression of STAT3 and STAT5b in Swedish and Egyptian patients with activated b-cell subtype of diffuse large b-cell lymphoma" @default.
- W2315018631 doi "https://doi.org/10.1158/1538-7445.am2011-5011" @default.
- W2315018631 hasPublicationYear "2011" @default.
- W2315018631 type Work @default.
- W2315018631 sameAs 2315018631 @default.
- W2315018631 citedByCount "0" @default.
- W2315018631 crossrefType "proceedings-article" @default.
- W2315018631 hasAuthorship W2315018631A5016320447 @default.
- W2315018631 hasAuthorship W2315018631A5019887534 @default.
- W2315018631 hasAuthorship W2315018631A5023600276 @default.
- W2315018631 hasAuthorship W2315018631A5030055287 @default.
- W2315018631 hasAuthorship W2315018631A5032924794 @default.
- W2315018631 hasAuthorship W2315018631A5038538552 @default.
- W2315018631 hasAuthorship W2315018631A5040702936 @default.
- W2315018631 hasAuthorship W2315018631A5069881022 @default.
- W2315018631 hasAuthorship W2315018631A5071309680 @default.
- W2315018631 hasConcept C104317684 @default.
- W2315018631 hasConcept C127561419 @default.
- W2315018631 hasConcept C142724271 @default.
- W2315018631 hasConcept C150194340 @default.
- W2315018631 hasConcept C159654299 @default.
- W2315018631 hasConcept C18431079 @default.
- W2315018631 hasConcept C203014093 @default.
- W2315018631 hasConcept C204232928 @default.
- W2315018631 hasConcept C2778453870 @default.
- W2315018631 hasConcept C2778559949 @default.
- W2315018631 hasConcept C2779338263 @default.
- W2315018631 hasConcept C502942594 @default.
- W2315018631 hasConcept C54355233 @default.
- W2315018631 hasConcept C71924100 @default.
- W2315018631 hasConcept C86803240 @default.
- W2315018631 hasConcept C96926380 @default.
- W2315018631 hasConceptScore W2315018631C104317684 @default.
- W2315018631 hasConceptScore W2315018631C127561419 @default.
- W2315018631 hasConceptScore W2315018631C142724271 @default.
- W2315018631 hasConceptScore W2315018631C150194340 @default.
- W2315018631 hasConceptScore W2315018631C159654299 @default.
- W2315018631 hasConceptScore W2315018631C18431079 @default.
- W2315018631 hasConceptScore W2315018631C203014093 @default.
- W2315018631 hasConceptScore W2315018631C204232928 @default.
- W2315018631 hasConceptScore W2315018631C2778453870 @default.
- W2315018631 hasConceptScore W2315018631C2778559949 @default.
- W2315018631 hasConceptScore W2315018631C2779338263 @default.
- W2315018631 hasConceptScore W2315018631C502942594 @default.
- W2315018631 hasConceptScore W2315018631C54355233 @default.
- W2315018631 hasConceptScore W2315018631C71924100 @default.
- W2315018631 hasConceptScore W2315018631C86803240 @default.
- W2315018631 hasConceptScore W2315018631C96926380 @default.
- W2315018631 hasLocation W23150186311 @default.
- W2315018631 hasOpenAccess W2315018631 @default.
- W2315018631 hasPrimaryLocation W23150186311 @default.
- W2315018631 hasRelatedWork W1522525997 @default.
- W2315018631 hasRelatedWork W1977592657 @default.
- W2315018631 hasRelatedWork W202789627 @default.
- W2315018631 hasRelatedWork W2081498512 @default.
- W2315018631 hasRelatedWork W2564661908 @default.
- W2315018631 hasRelatedWork W2564812995 @default.
- W2315018631 hasRelatedWork W2588434016 @default.
- W2315018631 hasRelatedWork W2591601406 @default.
- W2315018631 hasRelatedWork W2911458930 @default.
- W2315018631 hasRelatedWork W2978299159 @default.
- W2315018631 hasRelatedWork W2979865404 @default.
- W2315018631 hasRelatedWork W2980202418 @default.
- W2315018631 hasRelatedWork W2982808007 @default.
- W2315018631 hasRelatedWork W2990302949 @default.
- W2315018631 hasRelatedWork W2993991705 @default.
- W2315018631 hasRelatedWork W2994147959 @default.
- W2315018631 hasRelatedWork W3000100215 @default.
- W2315018631 hasRelatedWork W3024523177 @default.
- W2315018631 hasRelatedWork W3028780597 @default.
- W2315018631 hasRelatedWork W88660462 @default.
- W2315018631 isParatext "false" @default.
- W2315018631 isRetracted "false" @default.
- W2315018631 magId "2315018631" @default.
- W2315018631 workType "article" @default.