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- W2315059350 abstract "You have accessJournal of UrologyBladder Cancer: Superficial (I)1 Apr 20131701 ACCURACY OF THE EORTC RISK TABLES AND OF THE CUETO SCORING MODEL TO PREDICT OUTCOMES IN NON MUSCLE-INVASIVE UROTHELIAL CARCINOMA OF THE BLADDER Evanguelos xylinas, Matthew Kent, Dan Sjoberg, Luis Kluth, Armin Pycha, Evi Comploj, Yair Lotan, Robert Svatek, Quoc-Dien Trinh, Pierre Karakiewicz, Douglas Scherr, Marc Zerbib, and Shahrokh Shariat Evanguelos xylinasEvanguelos xylinas New York, NY More articles by this author , Matthew KentMatthew Kent New York, NY More articles by this author , Dan SjobergDan Sjoberg New York, NY More articles by this author , Luis KluthLuis Kluth New York, NY More articles by this author , Armin PychaArmin Pycha Bolzano, Italy More articles by this author , Evi ComplojEvi Comploj Bolzano, Italy More articles by this author , Yair LotanYair Lotan Dallas, Tx More articles by this author , Robert SvatekRobert Svatek Dallas, Tx More articles by this author , Quoc-Dien TrinhQuoc-Dien Trinh Montreal, Canada More articles by this author , Pierre KarakiewiczPierre Karakiewicz Montreal, Canada More articles by this author , Douglas ScherrDouglas Scherr New York, NY More articles by this author , Marc ZerbibMarc Zerbib Paris, France More articles by this author , and Shahrokh ShariatShahrokh Shariat New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.3011AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The European Organization for Research and Treatment of Cancer (EORTC) risk tables and the Spanish Urological Club for Oncological Treatment (CUETO) scoring model are the two best-established predictive tools to help decision-making for patients with non-muscle-invasive bladder cancer (NMIBC). The aim of the current study was to assess the performance of these predictive tools in a large multicenter cohort of NMIBC patients. METHODS We performed a retrospective analysis of 4689 patients with NMIBC treated between 1996 and 2007 at eight institutions. Bacillus Calmette-Guérin (BCG) immunotherapy was administered to 538 (11%) patients. We applied the EORTC and CUETO scoring methodology to our cohort to calculate each patients score. Using Kaplan-Meier methods, we then calculated each patient?s risk for disease recurrence and progression at the same time points of 1 and 5 years. To evaluate the discrimination of the risk tables, we created Cox proportional hazard regression models for time to recurrence and time to progression. We incorporated the patients calculated risk score as a predictor into both of these models and then calculated the concordance indexes for them. We compared the concordance index of our models to the concordance index reported in the initial EORTC and CUETO series. Calibration plots were also used to compare the predicted risks to the actual risks seen in our cohort. As additional analyses, we repeated the above analyses for patients who were treated with BCG to explore the robustness of both risk tables. RESULTS With a median follow-up of 57 months, 2110 patients (45%) experienced disease recurrence and 591 patients (12.5%) experienced disease progression. Both tools exhibited an over estimation of recurrence risks for patients with lower risk scores and under estimation of patients with higher risk scores. With regards to progression, both tools exhibited a poor calibration. There were no major changes when the analyses were restricted to patients treated with BCG. CONCLUSIONS The EORTC risk tables and the CUETO scoring system overestimated the risk of disease recurrence and progression in our multicenter cohort. These results underline the need for improving our current predictive tools by adding new prognostic factors such as pathological features and tissue-based markers, as well as continuously updating the calibration of predictive tools. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e700 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Evanguelos xylinas New York, NY More articles by this author Matthew Kent New York, NY More articles by this author Dan Sjoberg New York, NY More articles by this author Luis Kluth New York, NY More articles by this author Armin Pycha Bolzano, Italy More articles by this author Evi Comploj Bolzano, Italy More articles by this author Yair Lotan Dallas, Tx More articles by this author Robert Svatek Dallas, Tx More articles by this author Quoc-Dien Trinh Montreal, Canada More articles by this author Pierre Karakiewicz Montreal, Canada More articles by this author Douglas Scherr New York, NY More articles by this author Marc Zerbib Paris, France More articles by this author Shahrokh Shariat New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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- W2315059350 title "1701 ACCURACY OF THE EORTC RISK TABLES AND OF THE CUETO SCORING MODEL TO PREDICT OUTCOMES IN NON MUSCLE-INVASIVE UROTHELIAL CARCINOMA OF THE BLADDER" @default.
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