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- W23150724 abstract "The purpose of this chapter is to present an overview of our recent experience with vitamin E and ROP at University of Pennsylvania. Our interest in the vitamin for the prevention and treatment of retinopathy of prematurity (ROP) at Pennsylvania Hospital goes back to the early 1970’s when one of us (LJ) began a randomized trial in premature infants with birthweight (BW) ≤2000g of supplemental E to raise serum levels to the physiologic range (target serum level 1.5mg/dl). David Schaffer M.D. who had been doing ROP screening examinations in the nursery at Pennsylvania Hospital since 1968 was masked from treatment group assignment as were the parents and medical staff. The hypothesis which the protocol was designed to test was based on the presence of E deficiency at birth in premature infants and the fact that E is a potent antioxidant which theoretically should act to decrease damage from oxygen free radicals at several points on the pathway to cicatricial disease (1)." @default.
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- W23150724 date "1987-01-01" @default.
- W23150724 modified "2023-09-24" @default.
- W23150724 title "Vitamin E at Pharmacologic Serum Levels and Incidence, Progression and Cicatricial Residua of Retinopathy of Prematurity" @default.
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