Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315094691> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2315094691 endingPage "A119" @default.
- W2315094691 startingPage "A118" @default.
- W2315094691 abstract "Aspiration of gastric (acid) content is a major cause of acute respiratory failure that occurs in children with severe gastroesophageal reflux, gastrointestinal malformations, and neurologic impairment. Alveolar surfactant alterations were demonstrated in diseases with similar aetiology like ARDS and meconium aspiration syndrome. To understand if the surfactant system is modulated locally or if an unilateral injury influences both lungs, we measured alveolar surfactant DSPC in a murine model of unilateral acid injury. We developed a mouse model of acid lung injury confined in a single lung (right). Deuterated water was injected 18 h after the lung injury and DSPC-palmitate deuterium enrichment was measured for the next 24 hours in BAL and tissue. MPO and total protein analysis was performed separately to each lung to assess the inflammatory status. Inflammatory status of both lungs was markedly increased in the injured (right) lung. DSPC content was not significantly different between the two lungs in tissue homogenates at all time points (1.83±0.3 vs. 1.75±0.6 umol/g of lung). Conversely, DSPC content in BAL was significantly increased in the not-injured lung (1.00±0.36 vs. 1.49±0.5 umol/g of lung, p=0.008). Fractional synthetic rates did not significantly change in both homogenates and BAL between the two lungs. These preliminary data suggest that surfactant system is likely to be regulated at the whole lung level. The not-injured lung seems to increase the amount of DSPC in the alveolar space as a compensatory mechanism for the damage in the contralateral lung." @default.
- W2315094691 created "2016-06-24" @default.
- W2315094691 creator A5007617531 @default.
- W2315094691 creator A5018762143 @default.
- W2315094691 creator A5035500839 @default.
- W2315094691 creator A5037609194 @default.
- W2315094691 creator A5061276446 @default.
- W2315094691 creator A5066479375 @default.
- W2315094691 creator A5074943446 @default.
- W2315094691 creator A5081632225 @default.
- W2315094691 date "2012-10-01" @default.
- W2315094691 modified "2023-09-28" @default.
- W2315094691 title "404 Dspc-Palmitate Kinetic in A Model of Lung Unilateral Acid Injury" @default.
- W2315094691 doi "https://doi.org/10.1136/archdischild-2012-302724.0404" @default.
- W2315094691 hasPublicationYear "2012" @default.
- W2315094691 type Work @default.
- W2315094691 sameAs 2315094691 @default.
- W2315094691 citedByCount "0" @default.
- W2315094691 crossrefType "journal-article" @default.
- W2315094691 hasAuthorship W2315094691A5007617531 @default.
- W2315094691 hasAuthorship W2315094691A5018762143 @default.
- W2315094691 hasAuthorship W2315094691A5035500839 @default.
- W2315094691 hasAuthorship W2315094691A5037609194 @default.
- W2315094691 hasAuthorship W2315094691A5061276446 @default.
- W2315094691 hasAuthorship W2315094691A5066479375 @default.
- W2315094691 hasAuthorship W2315094691A5074943446 @default.
- W2315094691 hasAuthorship W2315094691A5081632225 @default.
- W2315094691 hasBestOaLocation W23150946911 @default.
- W2315094691 hasConcept C126322002 @default.
- W2315094691 hasConcept C134018914 @default.
- W2315094691 hasConcept C142724271 @default.
- W2315094691 hasConcept C172680121 @default.
- W2315094691 hasConcept C185592680 @default.
- W2315094691 hasConcept C2776348555 @default.
- W2315094691 hasConcept C2777714996 @default.
- W2315094691 hasConcept C2779234561 @default.
- W2315094691 hasConcept C2780745319 @default.
- W2315094691 hasConcept C2780985857 @default.
- W2315094691 hasConcept C534529494 @default.
- W2315094691 hasConcept C54355233 @default.
- W2315094691 hasConcept C55493867 @default.
- W2315094691 hasConcept C58226133 @default.
- W2315094691 hasConcept C71924100 @default.
- W2315094691 hasConcept C86803240 @default.
- W2315094691 hasConcept C90924648 @default.
- W2315094691 hasConceptScore W2315094691C126322002 @default.
- W2315094691 hasConceptScore W2315094691C134018914 @default.
- W2315094691 hasConceptScore W2315094691C142724271 @default.
- W2315094691 hasConceptScore W2315094691C172680121 @default.
- W2315094691 hasConceptScore W2315094691C185592680 @default.
- W2315094691 hasConceptScore W2315094691C2776348555 @default.
- W2315094691 hasConceptScore W2315094691C2777714996 @default.
- W2315094691 hasConceptScore W2315094691C2779234561 @default.
- W2315094691 hasConceptScore W2315094691C2780745319 @default.
- W2315094691 hasConceptScore W2315094691C2780985857 @default.
- W2315094691 hasConceptScore W2315094691C534529494 @default.
- W2315094691 hasConceptScore W2315094691C54355233 @default.
- W2315094691 hasConceptScore W2315094691C55493867 @default.
- W2315094691 hasConceptScore W2315094691C58226133 @default.
- W2315094691 hasConceptScore W2315094691C71924100 @default.
- W2315094691 hasConceptScore W2315094691C86803240 @default.
- W2315094691 hasConceptScore W2315094691C90924648 @default.
- W2315094691 hasIssue "Suppl 2" @default.
- W2315094691 hasLocation W23150946911 @default.
- W2315094691 hasLocation W23150946912 @default.
- W2315094691 hasOpenAccess W2315094691 @default.
- W2315094691 hasPrimaryLocation W23150946911 @default.
- W2315094691 hasRelatedWork W1966465698 @default.
- W2315094691 hasRelatedWork W1986846731 @default.
- W2315094691 hasRelatedWork W2017584377 @default.
- W2315094691 hasRelatedWork W2033335965 @default.
- W2315094691 hasRelatedWork W2034182290 @default.
- W2315094691 hasRelatedWork W2035876908 @default.
- W2315094691 hasRelatedWork W2061903286 @default.
- W2315094691 hasRelatedWork W2068044834 @default.
- W2315094691 hasRelatedWork W2170706305 @default.
- W2315094691 hasRelatedWork W2315094691 @default.
- W2315094691 hasVolume "97" @default.
- W2315094691 isParatext "false" @default.
- W2315094691 isRetracted "false" @default.
- W2315094691 magId "2315094691" @default.
- W2315094691 workType "article" @default.