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- W2315109918 abstract "1,4-Dichlorobenzene (1,4-DCB) is a wide-spread environmental contaminant and well-described hepatotoxicant for rats and mice. The prolonged oral or inhalation exposure to 1,4-DCB is associated with an increased frequency of hepatic tumors in mice, but not in rats. Evidence is lacking of direct genotoxicity with 1,4-DCB or its metabolites, and no generally accepted mechanism has been found to account for the increased numbers of 1,4-DCB-induced hepatic tumors in mice. No information is available on the carcinogenic effects of 1,4-DCB in humans. Here we consider evidence that the biotransformation of 1,4-DCB to substituted hydroquinone species contributes to hepatic adenoma and carcinoma formation in mouse liver. This phenomenon has implications for human carcinogenesis." @default.
- W2315109918 created "2016-06-24" @default.
- W2315109918 creator A5053921689 @default.
- W2315109918 date "2002-01-01" @default.
- W2315109918 modified "2023-10-17" @default.
- W2315109918 title "1,4-Dichlorobenzene-Induced Liver Tumors in the Mouse: Evaluation of the Role of Chlorohydroquinones" @default.
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- W2315109918 doi "https://doi.org/10.1515/reveh.2002.17.4.279" @default.
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