Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315123021> ?p ?o ?g. }
- W2315123021 endingPage "61" @default.
- W2315123021 startingPage "37" @default.
- W2315123021 abstract "In cardiac myocytes calcium (Ca) entry over the plasma membrane plays a crucial role in the cells electrophysiological properties. It determines the plateau of the cardiac action potential and forms the essential trigger that initiates Ca-induced Ca release and thereby cardiac excitation-contraction coupling. Ca can enter the cardiomyocyte during the action potential by the activation of voltage-dependent L-type and T-type Ca channels. While the electrogenic sodium-calcium exchanger (NCX) predominantly extrudes Ca from the cytoplasm, its dependence on the electrochemical driving force allows for Ca entry during depolarizing voltages when NCX operates in the reverse mode. In a ventricular myocyte the extend of Ca movement across the plasma membrane predominantly regulates cardiac contractility; however, these Ca-fluxes can also promote spontaneous activity. This can occur under physiological conditions during the diastolic depolarization of a cardiac pacemaker cell or under pathophysiological conditions when a dysregulation of Ca-fluxes allows for the generation of early or delayed after depolarizations. This kind of dysregulation can be observed during cardiac remodeling in the state of cardiac hypertrophy and heart failure. In this chapter the molecular and functional basis of Ca-fluxes across the plasma membrane and their changes during the cardiac remodeling process that leads to heart failure will be presented. We will discuss the importance of these changes for the increased propensity to arrhythmia as well as their contribution to the cardiac remodeling process itself." @default.
- W2315123021 created "2016-06-24" @default.
- W2315123021 creator A5018997286 @default.
- W2315123021 date "2013-01-01" @default.
- W2315123021 modified "2023-09-27" @default.
- W2315123021 title "Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes" @default.
- W2315123021 cites W1481378243 @default.
- W2315123021 cites W1496382049 @default.
- W2315123021 cites W1526862534 @default.
- W2315123021 cites W1551217436 @default.
- W2315123021 cites W1574790479 @default.
- W2315123021 cites W1963528850 @default.
- W2315123021 cites W1963623014 @default.
- W2315123021 cites W1965035060 @default.
- W2315123021 cites W1965543995 @default.
- W2315123021 cites W1966072563 @default.
- W2315123021 cites W1968311622 @default.
- W2315123021 cites W1971214746 @default.
- W2315123021 cites W1971836552 @default.
- W2315123021 cites W1976398898 @default.
- W2315123021 cites W1979898903 @default.
- W2315123021 cites W1981261137 @default.
- W2315123021 cites W1981607442 @default.
- W2315123021 cites W1982871296 @default.
- W2315123021 cites W1983978847 @default.
- W2315123021 cites W1986866353 @default.
- W2315123021 cites W1987416588 @default.
- W2315123021 cites W1990225504 @default.
- W2315123021 cites W1990450421 @default.
- W2315123021 cites W1991131183 @default.
- W2315123021 cites W1992578125 @default.
- W2315123021 cites W1993536160 @default.
- W2315123021 cites W1993850699 @default.
- W2315123021 cites W1995005951 @default.
- W2315123021 cites W1997677285 @default.
- W2315123021 cites W1998299402 @default.
- W2315123021 cites W1998672281 @default.
- W2315123021 cites W1999515062 @default.
- W2315123021 cites W2004403903 @default.
- W2315123021 cites W2007388823 @default.
- W2315123021 cites W2008858665 @default.
- W2315123021 cites W2009765916 @default.
- W2315123021 cites W2011338378 @default.
- W2315123021 cites W2012691619 @default.
- W2315123021 cites W2014359610 @default.
- W2315123021 cites W2014970043 @default.
- W2315123021 cites W2015285707 @default.
- W2315123021 cites W2021693681 @default.
- W2315123021 cites W2021968322 @default.
- W2315123021 cites W2022582268 @default.
- W2315123021 cites W2023169137 @default.
- W2315123021 cites W2026968419 @default.
- W2315123021 cites W2027230646 @default.
- W2315123021 cites W2027746506 @default.
- W2315123021 cites W2028296474 @default.
- W2315123021 cites W2030267203 @default.
- W2315123021 cites W2030698636 @default.
- W2315123021 cites W2032781215 @default.
- W2315123021 cites W2034271910 @default.
- W2315123021 cites W2036607708 @default.
- W2315123021 cites W2036937904 @default.
- W2315123021 cites W2037398721 @default.
- W2315123021 cites W2039186292 @default.
- W2315123021 cites W2042824083 @default.
- W2315123021 cites W2044286733 @default.
- W2315123021 cites W2046701128 @default.
- W2315123021 cites W2048777704 @default.
- W2315123021 cites W2050956829 @default.
- W2315123021 cites W2051461374 @default.
- W2315123021 cites W2053798040 @default.
- W2315123021 cites W2054554932 @default.
- W2315123021 cites W2055571680 @default.
- W2315123021 cites W2057471044 @default.
- W2315123021 cites W2058607911 @default.
- W2315123021 cites W2058695701 @default.
- W2315123021 cites W2059201211 @default.
- W2315123021 cites W2060072866 @default.
- W2315123021 cites W2060543464 @default.
- W2315123021 cites W2062997685 @default.
- W2315123021 cites W2066092841 @default.
- W2315123021 cites W2068822694 @default.
- W2315123021 cites W2070500034 @default.
- W2315123021 cites W2073101309 @default.
- W2315123021 cites W2073398681 @default.
- W2315123021 cites W2074102566 @default.
- W2315123021 cites W2074940395 @default.
- W2315123021 cites W2082470387 @default.
- W2315123021 cites W2084650980 @default.
- W2315123021 cites W2087062865 @default.
- W2315123021 cites W2087941444 @default.
- W2315123021 cites W2089049354 @default.
- W2315123021 cites W2090469118 @default.
- W2315123021 cites W2091100988 @default.
- W2315123021 cites W2091968002 @default.
- W2315123021 cites W2092643356 @default.
- W2315123021 cites W2096667649 @default.
- W2315123021 cites W2096795369 @default.
- W2315123021 cites W2098367638 @default.