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• W2315129148 abstract "The microenvironment influences the pathogenesis of solid tumors and plays an outsized role in some. Our understanding of the stromal response to cancers, particularly pancreatic ductal adenocarcinoma, has evolved from that of host defense to tumor offense. We know that most, although not all, of the factors and processes in the microenvironment support tumor epithelial cells. This reappraisal of the roles of stromal elements has also revealed potential vulnerabilities and therapeutic opportunities to exploit. The high concentration in the stroma of the glycosaminoglycan hyaluronan, together with the large gel-fluid phase and pressures it generates, were recently identified as primary sources of treatment resistance in pancreas cancer. Whereas the relatively minor role of free interstitial fluid in the fluid mechanics and perfusion of tumors has been long appreciated, the less mobile, gel-fluid phase has been largely ignored for historical and technical reasons. The inability of classic methods of fluid pressure measurement to capture the gel-fluid phase, together with a dependence on xenograft and allograft systems that inaccurately model tumor vascular biology, has led to an undue emphasis on the role of free fluid in impeding perfusion and drug delivery and an almost complete oversight of the predominant role of the gel-fluid phase. We propose that a hyaluronan-rich, relatively immobile gel-fluid phase induces vascular collapse and hypoperfusion as a primary mechanism of treatment resistance in pancreas cancers. Similar properties may be operant in other solid tumors as well, so revisiting and characterizing fluid mechanics with modern techniques in other autochthonous cancers may be warranted." @default.
• W2315129148 created "2016-06-24" @default.
• W2315129148 creator A5013925502 @default.
• W2315129148 creator A5031234698 @default.
• W2315129148 creator A5079776393 @default.
• W2315129148 date "2016-06-01" @default.
• W2315129148 modified "2023-10-13" @default.
• W2315129148 title "Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma" @default.
• W2315129148 cites W1517495250 @default.
• W2315129148 cites W1548038016 @default.
• W2315129148 cites W1593247367 @default.
• W2315129148 cites W1656339735 @default.
• W2315129148 cites W1698380454 @default.
• W2315129148 cites W1839781125 @default.
• W2315129148 cites W1843966557 @default.
• W2315129148 cites W1921630717 @default.
• W2315129148 cites W1963482033 @default.
• W2315129148 cites W1968078362 @default.
• W2315129148 cites W1974351257 @default.
• W2315129148 cites W1981471842 @default.
• W2315129148 cites W1987515890 @default.
• W2315129148 cites W1988927889 @default.
• W2315129148 cites W1990983926 @default.
• W2315129148 cites W1992995822 @default.
• W2315129148 cites W1994877146 @default.
• W2315129148 cites W1996912024 @default.
• W2315129148 cites W1998266575 @default.
• W2315129148 cites W2001679453 @default.
• W2315129148 cites W2002268410 @default.
• W2315129148 cites W2005082047 @default.
• W2315129148 cites W2008324315 @default.
• W2315129148 cites W2010967591 @default.
• W2315129148 cites W2012124753 @default.
• W2315129148 cites W2012241134 @default.
• W2315129148 cites W2013926680 @default.
• W2315129148 cites W2014282546 @default.
• W2315129148 cites W2022093822 @default.
• W2315129148 cites W2023836634 @default.
• W2315129148 cites W2025036947 @default.
• W2315129148 cites W2028156849 @default.
• W2315129148 cites W2032986552 @default.
• W2315129148 cites W2033878276 @default.
• W2315129148 cites W2035536358 @default.
• W2315129148 cites W2043967411 @default.
• W2315129148 cites W2045295282 @default.
• W2315129148 cites W2052617606 @default.
• W2315129148 cites W2053761380 @default.
• W2315129148 cites W2054034979 @default.
• W2315129148 cites W2054627635 @default.
• W2315129148 cites W2055091294 @default.
• W2315129148 cites W2057987728 @default.
• W2315129148 cites W2062075300 @default.
• W2315129148 cites W2063916984 @default.
• W2315129148 cites W2066135299 @default.
• W2315129148 cites W2066365544 @default.
• W2315129148 cites W2068442933 @default.
• W2315129148 cites W2068734467 @default.
• W2315129148 cites W2069977936 @default.
• W2315129148 cites W2070779203 @default.
• W2315129148 cites W2073359472 @default.
• W2315129148 cites W2075884354 @default.
• W2315129148 cites W2082770504 @default.
• W2315129148 cites W2082898208 @default.
• W2315129148 cites W2088110734 @default.
• W2315129148 cites W2089232392 @default.
• W2315129148 cites W2089753996 @default.
• W2315129148 cites W2090453278 @default.
• W2315129148 cites W2095741501 @default.
• W2315129148 cites W2096334365 @default.
• W2315129148 cites W2100273059 @default.
• W2315129148 cites W2104604857 @default.
• W2315129148 cites W2107338023 @default.
• W2315129148 cites W2107441200 @default.
• W2315129148 cites W2107618142 @default.
• W2315129148 cites W2109958848 @default.
• W2315129148 cites W2115359512 @default.
• W2315129148 cites W2115780849 @default.
• W2315129148 cites W2117692326 @default.
• W2315129148 cites W2126663928 @default.
• W2315129148 cites W2127329148 @default.
• W2315129148 cites W2130464657 @default.
• W2315129148 cites W2131095105 @default.
• W2315129148 cites W2131516162 @default.
• W2315129148 cites W2133758413 @default.
• W2315129148 cites W2137217704 @default.
• W2315129148 cites W2138060624 @default.
• W2315129148 cites W2139248843 @default.
• W2315129148 cites W2150516757 @default.
• W2315129148 cites W2155783433 @default.
• W2315129148 cites W2161744213 @default.
• W2315129148 cites W2163308073 @default.
• W2315129148 cites W2168467781 @default.
• W2315129148 cites W2181049752 @default.
• W2315129148 cites W2248264350 @default.
• W2315129148 cites W2259627090 @default.
• W2315129148 cites W2313603984 @default.
• W2315129148 cites W2314203153 @default.
• W2315129148 cites W2397566729 @default.

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