Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315133059> ?p ?o ?g. }
- W2315133059 abstract "Bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease (DOHaD) effects in his offspring. Such effects could be due to the seminal fluid, which is slightly basic and enriched with carbohydrates; thereby, creating an ideal habitat for microbes or a potential seminal fluid microbiome (SFM). Using wild-type (WT) and estrogen receptor-alpha (ESR1) knockout (KO) male mice, we describe a unique SFM whose inhabitants differ from gut microbes. The bacterial composition of the SFM is influenced according to whether mice have functional Esr1 genes. Propionibacterium acnes, causative agent of chronic prostatitis possibly culminating in prostate cancer, is reduced in SFM of ESR1 KO compared to WT mice (P ≤ 0.0007). In certain genetic backgrounds, WT mice show a greater incidence of prostate cancer than ESR1 KO, which may be due to increased abundance of P. acnes. Additionally, select gut microbiome residents in ESR1 KO males, such as Lachnospiraceae and Christensenellaceae, might contribute to previously identified phenotypes, especially obesity, in these mutant mice. Understanding how genetics and environmental factors influence the SFM may provide the next frontier in male reproductive disorders and possibly paternal-based DOHaD diseases." @default.
- W2315133059 created "2016-06-24" @default.
- W2315133059 creator A5002367027 @default.
- W2315133059 creator A5012988162 @default.
- W2315133059 creator A5034582554 @default.
- W2315133059 creator A5040355364 @default.
- W2315133059 creator A5050133254 @default.
- W2315133059 creator A5053902032 @default.
- W2315133059 creator A5058515084 @default.
- W2315133059 creator A5065933684 @default.
- W2315133059 creator A5072471830 @default.
- W2315133059 creator A5090943412 @default.
- W2315133059 date "2016-03-14" @default.
- W2315133059 modified "2023-10-03" @default.
- W2315133059 title "Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status" @default.
- W2315133059 cites W1526516695 @default.
- W2315133059 cites W1552775957 @default.
- W2315133059 cites W1576927780 @default.
- W2315133059 cites W1910049290 @default.
- W2315133059 cites W1949928978 @default.
- W2315133059 cites W1964570785 @default.
- W2315133059 cites W1968224752 @default.
- W2315133059 cites W1970783900 @default.
- W2315133059 cites W1976589392 @default.
- W2315133059 cites W1976684529 @default.
- W2315133059 cites W1982203245 @default.
- W2315133059 cites W1986062308 @default.
- W2315133059 cites W1988925586 @default.
- W2315133059 cites W1999014709 @default.
- W2315133059 cites W1999186712 @default.
- W2315133059 cites W1999856644 @default.
- W2315133059 cites W2000946095 @default.
- W2315133059 cites W2005813248 @default.
- W2315133059 cites W2007110604 @default.
- W2315133059 cites W2007128729 @default.
- W2315133059 cites W2009516824 @default.
- W2315133059 cites W2017027430 @default.
- W2315133059 cites W2025407650 @default.
- W2315133059 cites W2026006003 @default.
- W2315133059 cites W2027292673 @default.
- W2315133059 cites W2033829415 @default.
- W2315133059 cites W2038334842 @default.
- W2315133059 cites W2040233717 @default.
- W2315133059 cites W2043516268 @default.
- W2315133059 cites W2055090281 @default.
- W2315133059 cites W2055244748 @default.
- W2315133059 cites W2056279562 @default.
- W2315133059 cites W2059632047 @default.
- W2315133059 cites W2061478086 @default.
- W2315133059 cites W2065775374 @default.
- W2315133059 cites W2068794826 @default.
- W2315133059 cites W2072970694 @default.
- W2315133059 cites W2073122969 @default.
- W2315133059 cites W2073353512 @default.
- W2315133059 cites W2077072558 @default.
- W2315133059 cites W2080283023 @default.
- W2315133059 cites W2080578593 @default.
- W2315133059 cites W2081313422 @default.
- W2315133059 cites W2086275477 @default.
- W2315133059 cites W2086690715 @default.
- W2315133059 cites W2087579364 @default.
- W2315133059 cites W2090232168 @default.
- W2315133059 cites W2095885321 @default.
- W2315133059 cites W2096748963 @default.
- W2315133059 cites W2106731207 @default.
- W2315133059 cites W2106798170 @default.
- W2315133059 cites W2108160091 @default.
- W2315133059 cites W2109654257 @default.
- W2315133059 cites W2110300022 @default.
- W2315133059 cites W2111525597 @default.
- W2315133059 cites W2112120380 @default.
- W2315133059 cites W2113418799 @default.
- W2315133059 cites W2113576333 @default.
- W2315133059 cites W2122733141 @default.
- W2315133059 cites W2123117545 @default.
- W2315133059 cites W2124351063 @default.
- W2315133059 cites W2130597092 @default.
- W2315133059 cites W2133856765 @default.
- W2315133059 cites W2134868253 @default.
- W2315133059 cites W2137068383 @default.
- W2315133059 cites W2138330280 @default.
- W2315133059 cites W2142942734 @default.
- W2315133059 cites W2144573094 @default.
- W2315133059 cites W2151784714 @default.
- W2315133059 cites W2152343110 @default.
- W2315133059 cites W2155741274 @default.
- W2315133059 cites W2157107905 @default.
- W2315133059 cites W2161536630 @default.
- W2315133059 cites W2166236051 @default.
- W2315133059 cites W2201382378 @default.
- W2315133059 cites W2210080033 @default.
- W2315133059 doi "https://doi.org/10.1038/srep23027" @default.
- W2315133059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4789797" @default.
- W2315133059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26971397" @default.
- W2315133059 hasPublicationYear "2016" @default.
- W2315133059 type Work @default.
- W2315133059 sameAs 2315133059 @default.
- W2315133059 citedByCount "54" @default.
- W2315133059 countsByYear W23151330592016 @default.
- W2315133059 countsByYear W23151330592017 @default.