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- W2315224359 abstract "Terpinen-4-ol, an active component of tea tree oil, exhibits broad-spectrum antimicrobial activity. However, the high volatilization of terpinen-4-ol and its nonwettability property have limited its application. Our objective was to synthesize novel nanocarriers to deliver and protect terpinen-4-ol. The polyethylene glycol (PEG)-stabilized lipid nanoparticles were prepared and characterized by scanning electron microscope, Zetasizer, and differential scanning calorimetry. These nanoparticles had an average diameter of 397 nm and a Ζ-potential of 10 mV after being modified by glycine. Results showed that homogeneous particle size, high drug loading, stability, and targeting were obtained by the nanoparticles. Liquid chromatography/mass spectrometry showed a sustained release trend from nanoparticles for terpinen-4-ol. Minimum inhibitory concentration and minimum biofilm eradication concentration were tested against Candida albicans ATCC 11231. Studies on isolated mitochondria showed the blockage of biofilm respiration and inhibition of enzyme activity. The effects can be ascribed to localization of terpinen-4-ol on the membrane of mitochondria." @default.
- W2315224359 created "2016-06-24" @default.
- W2315224359 creator A5066081640 @default.
- W2315224359 creator A5079498998 @default.
- W2315224359 creator A5082119775 @default.
- W2315224359 date "2012-06-11" @default.
- W2315224359 modified "2023-09-30" @default.
- W2315224359 title "Characterization, Antibiofilm, and Mechanism of Action of Novel PEG-Stabilized Lipid Nanoparticles Loaded with Terpinen-4-ol" @default.
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- W2315224359 doi "https://doi.org/10.1021/jf3010405" @default.
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