FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315262058> ?p ?o ?g. }

• W2315262058 endingPage "875" @default.
• W2315262058 startingPage "868" @default.
• W2315262058 abstract "Two radiolabeled analogues of 6-benzyloxy-9H-purin-2-ylamine (O(6)-benzylguanine; BG) potentially useful in the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase (AGT) were synthesized. Fluorine-18 labeling of the known 6-(4-fluoro-benzyloxy)-9H-purin-2-ylamine (FBG; 6) was accomplished by the condensation of 4-[(18)F]fluorobenzyl alcohol with 2-aminopurin-6-yltrimethylammonium chloride (4) or 2-amino-6-chloropurine in average decay-corrected radiochemical yields of 40 and 25%, respectively. Unlabeled 6-(3-iodo-benzyloxy)-9H-purin-2-ylamine (IBG; 7) was prepared from 4 and 3-iodobenzyl alcohol. Radioiodination of 9, prepared from 7 in two steps, and subsequent deprotection gave [(131)I]7 in about 70% overall radiochemical yield. The IC(50) values for the inactivation of AGT from CHO cells transfected with pCMV-AGT were 15 nM for IBG and 50 nM for FBG. The binding of [(18)F]6 and [(131)I]7 to purified AGT was specific and saturable with both exhibiting similar IC(50) values (5-6 microM)." @default.
• W2315262058 created "2016-06-24" @default.
• W2315262058 creator A5003562375 @default.
• W2315262058 creator A5005293523 @default.
• W2315262058 creator A5017101332 @default.
• W2315262058 creator A5021893284 @default.
• W2315262058 creator A5045964365 @default.
• W2315262058 creator A5057371623 @default.
• W2315262058 creator A5061678998 @default.
• W2315262058 creator A5070623669 @default.
• W2315262058 date "2000-10-25" @default.
• W2315262058 modified "2023-10-15" @default.
• W2315262058 title "Radiolabeled Guanine Derivatives for the in Vivo Mapping of <i>O</i>⁶-Alkylguanine-DNA Alkyltransferase: 6-(4-[¹⁸F]Fluoro-benzyloxy)-9<i>H</i>-purin-2-ylamine and 6-(3-[¹³¹I]Iodo-benzyloxy)-9<i>H</i>-purin-2-ylamine" @default.
• W2315262058 cites W1965745813 @default.
• W2315262058 cites W1996999985 @default.
• W2315262058 cites W1998842819 @default.
• W2315262058 cites W2001643046 @default.
• W2315262058 cites W2002378112 @default.
• W2315262058 cites W2012877046 @default.
• W2315262058 cites W2024971128 @default.
• W2315262058 cites W2032152522 @default.
• W2315262058 cites W2054073363 @default.
• W2315262058 cites W2064444558 @default.
• W2315262058 cites W2068767544 @default.
• W2315262058 cites W2083287304 @default.
• W2315262058 cites W2085564578 @default.
• W2315262058 cites W2089431716 @default.
• W2315262058 cites W2120593343 @default.
• W2315262058 cites W2154332455 @default.
• W2315262058 cites W2166382251 @default.
• W2315262058 cites W2950329210 @default.
• W2315262058 doi "https://doi.org/10.1021/bc0000435" @default.
• W2315262058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11087336" @default.
• W2315262058 hasPublicationYear "2000" @default.
• W2315262058 type Work @default.
• W2315262058 sameAs 2315262058 @default.
• W2315262058 citedByCount "18" @default.
• W2315262058 countsByYear W23152620582013 @default.
• W2315262058 countsByYear W23152620582019 @default.
• W2315262058 countsByYear W23152620582021 @default.
• W2315262058 countsByYear W23152620582023 @default.
• W2315262058 crossrefType "journal-article" @default.
• W2315262058 hasAuthorship W2315262058A5003562375 @default.
• W2315262058 hasAuthorship W2315262058A5005293523 @default.
• W2315262058 hasAuthorship W2315262058A5017101332 @default.
• W2315262058 hasAuthorship W2315262058A5021893284 @default.
• W2315262058 hasAuthorship W2315262058A5045964365 @default.
• W2315262058 hasAuthorship W2315262058A5057371623 @default.
• W2315262058 hasAuthorship W2315262058A5061678998 @default.
• W2315262058 hasAuthorship W2315262058A5070623669 @default.
• W2315262058 hasConcept C104317684 @default.
• W2315262058 hasConcept C134121241 @default.
• W2315262058 hasConcept C150903083 @default.
• W2315262058 hasConcept C178790620 @default.
• W2315262058 hasConcept C185592680 @default.
• W2315262058 hasConcept C191897082 @default.
• W2315262058 hasConcept C192562407 @default.
• W2315262058 hasConcept C207001950 @default.
• W2315262058 hasConcept C2778301229 @default.
• W2315262058 hasConcept C2778695967 @default.
• W2315262058 hasConcept C2781066024 @default.
• W2315262058 hasConcept C512185932 @default.
• W2315262058 hasConcept C552990157 @default.
• W2315262058 hasConcept C55493867 @default.
• W2315262058 hasConcept C71240020 @default.
• W2315262058 hasConcept C86803240 @default.
• W2315262058 hasConceptScore W2315262058C104317684 @default.
• W2315262058 hasConceptScore W2315262058C134121241 @default.
• W2315262058 hasConceptScore W2315262058C150903083 @default.
• W2315262058 hasConceptScore W2315262058C178790620 @default.
• W2315262058 hasConceptScore W2315262058C185592680 @default.
• W2315262058 hasConceptScore W2315262058C191897082 @default.
• W2315262058 hasConceptScore W2315262058C192562407 @default.
• W2315262058 hasConceptScore W2315262058C207001950 @default.
• W2315262058 hasConceptScore W2315262058C2778301229 @default.
• W2315262058 hasConceptScore W2315262058C2778695967 @default.
• W2315262058 hasConceptScore W2315262058C2781066024 @default.
• W2315262058 hasConceptScore W2315262058C512185932 @default.
• W2315262058 hasConceptScore W2315262058C552990157 @default.
• W2315262058 hasConceptScore W2315262058C55493867 @default.
• W2315262058 hasConceptScore W2315262058C71240020 @default.
• W2315262058 hasConceptScore W2315262058C86803240 @default.
• W2315262058 hasIssue "6" @default.
• W2315262058 hasLocation W23152620581 @default.
• W2315262058 hasLocation W23152620582 @default.
• W2315262058 hasOpenAccess W2315262058 @default.
• W2315262058 hasPrimaryLocation W23152620581 @default.
• W2315262058 hasRelatedWork W1988229946 @default.
• W2315262058 hasRelatedWork W2071460638 @default.
• W2315262058 hasRelatedWork W2073856947 @default.
• W2315262058 hasRelatedWork W2094219018 @default.
• W2315262058 hasRelatedWork W2373684426 @default.
• W2315262058 hasRelatedWork W2401463829 @default.
• W2315262058 hasRelatedWork W2949184651 @default.
• W2315262058 hasRelatedWork W2950122242 @default.
• W2315262058 hasRelatedWork W2950847194 @default.
• W2315262058 hasRelatedWork W2952649848 @default.
• W2315262058 hasVolume "11" @default.

• next