FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315276815> ?p ?o ?g. }

• W2315276815 endingPage "402" @default.
• W2315276815 startingPage "387" @default.
• W2315276815 abstract "Intracerebral-intraventricular hemorrhages (ICH/IVH) in very preterm neonates are responsible for high mortality and subsequent disabilities. In humans, tissue plasminogen activator (t-PA) initiates fibrinolysis and activates endoluminal-endothelial receptors; dysfunction of the t-PA inhibitor (PAI-1) results in recurrent hemorrhages. We used PAI-1 knockout (PAI-1−/−) mice to examine the role of t-PA in age-dependent intracranial hemorrhages as a possible model of preterm ICH/IVH. Intracortical injection of 2 μL of phosphate-buffered saline produced a small traumatic injury and a high rate of hemorrhage in PAI-1−/− pups at postnatal day 3 (P3) or P5, whereas it had no effect in wild-type neonates. This resulted in white matter and cortical lesions, ventricle enlargement, hyperlocomotion, and altered cortical levels of serotonin and dopamine in the adult PAI−/− mice. N-methyl-D-aspartate receptor blockers, plasmin- and matrix metalloproteinases inhibitors reduced hemorrhage and tissue lesions. In contrast to P3 to P5, no significant hemorrhages were induced in P10 PAI-1−/− pups and there were no behavioral or neurochemical alterations in adulthood. These data suggest that microvascular immaturity up to P5 in mice is a determinant factor required for t-PA–dependent vascular rupture. Neonatal PAI-1−/− mice could be a useful ICH/IVH model for studying the ontogenic window of vascular immaturity and vascular protection against later neurodisabilities." @default.
• W2315276815 created "2016-06-24" @default.
• W2315276815 creator A5001513885 @default.
• W2315276815 creator A5002901463 @default.
• W2315276815 creator A5013133934 @default.
• W2315276815 creator A5019948819 @default.
• W2315276815 creator A5023247351 @default.
• W2315276815 creator A5047152113 @default.
• W2315276815 creator A5057535169 @default.
• W2315276815 creator A5083524565 @default.
• W2315276815 creator A5087702875 @default.
• W2315276815 date "2014-05-01" @default.
• W2315276815 modified "2023-10-17" @default.
• W2315276815 title "Age-Dependent Neonatal Intracerebral Hemorrhage in Plasminogen Activator Inhibitor 1 Knockout Mice" @default.
• W2315276815 cites W1965064543 @default.
• W2315276815 cites W1966739276 @default.
• W2315276815 cites W1976478686 @default.
• W2315276815 cites W1982088484 @default.
• W2315276815 cites W1984970076 @default.
• W2315276815 cites W1987169870 @default.
• W2315276815 cites W1989734825 @default.
• W2315276815 cites W1994561821 @default.
• W2315276815 cites W1997420295 @default.
• W2315276815 cites W2012921623 @default.
• W2315276815 cites W2014848130 @default.
• W2315276815 cites W2016918804 @default.
• W2315276815 cites W2023144530 @default.
• W2315276815 cites W2023604378 @default.
• W2315276815 cites W2024049360 @default.
• W2315276815 cites W2028133356 @default.
• W2315276815 cites W2028850351 @default.
• W2315276815 cites W2029180093 @default.
• W2315276815 cites W2030999023 @default.
• W2315276815 cites W2039403376 @default.
• W2315276815 cites W2049744969 @default.
• W2315276815 cites W2053456759 @default.
• W2315276815 cites W2093601035 @default.
• W2315276815 cites W2093989434 @default.
• W2315276815 cites W2108397868 @default.
• W2315276815 cites W2114150640 @default.
• W2315276815 cites W2115756863 @default.
• W2315276815 cites W2119047274 @default.
• W2315276815 cites W2123993864 @default.
• W2315276815 cites W2126013477 @default.
• W2315276815 cites W2131690076 @default.
• W2315276815 cites W2148373446 @default.
• W2315276815 cites W2155940571 @default.
• W2315276815 cites W2171781946 @default.
• W2315276815 cites W4252878807 @default.
• W2315276815 doi "https://doi.org/10.1097/nen.0000000000000062" @default.
• W2315276815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24709679" @default.
• W2315276815 hasPublicationYear "2014" @default.
• W2315276815 type Work @default.
• W2315276815 sameAs 2315276815 @default.
• W2315276815 citedByCount "12" @default.
• W2315276815 countsByYear W23152768152015 @default.
• W2315276815 countsByYear W23152768152016 @default.
• W2315276815 countsByYear W23152768152017 @default.
• W2315276815 countsByYear W23152768152018 @default.
• W2315276815 countsByYear W23152768152020 @default.
• W2315276815 countsByYear W23152768152021 @default.
• W2315276815 crossrefType "journal-article" @default.
• W2315276815 hasAuthorship W2315276815A5001513885 @default.
• W2315276815 hasAuthorship W2315276815A5002901463 @default.
• W2315276815 hasAuthorship W2315276815A5013133934 @default.
• W2315276815 hasAuthorship W2315276815A5019948819 @default.
• W2315276815 hasAuthorship W2315276815A5023247351 @default.
• W2315276815 hasAuthorship W2315276815A5047152113 @default.
• W2315276815 hasAuthorship W2315276815A5057535169 @default.
• W2315276815 hasAuthorship W2315276815A5083524565 @default.
• W2315276815 hasAuthorship W2315276815A5087702875 @default.
• W2315276815 hasBestOaLocation W23152768151 @default.
• W2315276815 hasConcept C126322002 @default.
• W2315276815 hasConcept C134018914 @default.
• W2315276815 hasConcept C170493617 @default.
• W2315276815 hasConcept C181199279 @default.
• W2315276815 hasConcept C182704531 @default.
• W2315276815 hasConcept C25876315 @default.
• W2315276815 hasConcept C2776572282 @default.
• W2315276815 hasConcept C2776825266 @default.
• W2315276815 hasConcept C2777094939 @default.
• W2315276815 hasConcept C2777736543 @default.
• W2315276815 hasConcept C2778376644 @default.
• W2315276815 hasConcept C2779234561 @default.
• W2315276815 hasConcept C2779252433 @default.
• W2315276815 hasConcept C2779679481 @default.
• W2315276815 hasConcept C2780675426 @default.
• W2315276815 hasConcept C2781071845 @default.
• W2315276815 hasConcept C54355233 @default.
• W2315276815 hasConcept C55493867 @default.
• W2315276815 hasConcept C71924100 @default.
• W2315276815 hasConcept C86803240 @default.
• W2315276815 hasConceptScore W2315276815C126322002 @default.
• W2315276815 hasConceptScore W2315276815C134018914 @default.
• W2315276815 hasConceptScore W2315276815C170493617 @default.
• W2315276815 hasConceptScore W2315276815C181199279 @default.
• W2315276815 hasConceptScore W2315276815C182704531 @default.
• W2315276815 hasConceptScore W2315276815C25876315 @default.

• next