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• W2315301042 abstract "When examined histologically, clinical leukoplakia of the vulva in the postmenopausal female exhibits features of lichen sclerosus et atrophicus (LSA) in most cases. Leukoplakia of the vulva has long been regarded as premalignant and in a number of previous series of invasive squamous carcinoma of the vulva, LSA was reported to be seen in association with the carcinoma in only 10–50% of cases. During the 12-yr period 1966–77, we have examined 924 tissue specimens of the vulva. Of these, 157 were malignant lesions, 106 being invasive squamous carcinoma and 36 being carcinoma in situ. A review of the pathological material taken from vulvectomy specimens of all the invasive squamous carcinoma in postmenopausal females disclosed that when 5–10 tissue blocks of the tumour and the vulval skin were examined, the association with LSA was 20–30%. However, when 15–30 blocks were examined, the association was 60–70%, many showing multifocal microinvasive carcinoma arising in areas of LSA while others showed adjacent LSA with dysplastic epithelium. Therefore, to assess reliably the distribution, incidence and premalignant potential of vulval LSA with squamous carcinoma, adequate tissue sampling of the primary tumour and the adjacent skin has to be done. When examined histologically, clinical leukoplakia of the vulva in the postmenopausal female exhibits features of lichen sclerosus et atrophicus (LSA) in most cases. Leukoplakia of the vulva has long been regarded as premalignant and in a number of previous series of invasive squamous carcinoma of the vulva, LSA was reported to be seen in association with the carcinoma in only 10–50% of cases. During the 12-yr period 1966–77, we have examined 924 tissue specimens of the vulva. Of these, 157 were malignant lesions, 106 being invasive squamous carcinoma and 36 being carcinoma in situ. A review of the pathological material taken from vulvectomy specimens of all the invasive squamous carcinoma in postmenopausal females disclosed that when 5–10 tissue blocks of the tumour and the vulval skin were examined, the association with LSA was 20–30%. However, when 15–30 blocks were examined, the association was 60–70%, many showing multifocal microinvasive carcinoma arising in areas of LSA while others showed adjacent LSA with dysplastic epithelium. Therefore, to assess reliably the distribution, incidence and premalignant potential of vulval LSA with squamous carcinoma, adequate tissue sampling of the primary tumour and the adjacent skin has to be done." @default.
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• W2315301042 date "1978-01-01" @default.
• W2315301042 modified "2023-10-16" @default.
• W2315301042 title "A pathological study of the relationship between lichen sclerosus et atrophicus and squamous carcinoma of the vulva" @default.
• W2315301042 doi "https://doi.org/10.1016/s0031-3025(16)38662-7" @default.
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