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- W2315331603 abstract "The duration of the cell cycle and the pattern of chromosome replication throughout the S period are studied in the bone marrow of the rat in vivo. From the analysis of 610 metaphases and 140 karyotypes with their corresponding autoradiographs it can be concluded:1. The cell generation time is about 15 hours; the G1 period is about 4 hours; the S period lasts 7 hours and the G2 period comprises 2 to 3 hours.2. The study of the labeling over the chromosomes allows the distinguishing of four different patterns corresponding to the initial, intermediate, late and final stages of the S phase.3. The results obtained indicate that chromosomes start replication over partial areas. Later they extend DNA synthesis to their total length and at the final S stage only small replicating zones-not those at the starting point-can be detected over the chromosomes.4. Observation about the chronology of chromosome replication point out that different pairs of chromosomes start and finish DNA synthesis at different moments. Homologue asynchrony was detected as much as at the beginning as at the end of the S phase.5. The X chromosomes are among those which start replication the earliest; finishing DNA synthesis before several other pairs. In no case a late replicating X chromosome is observed.6. The Y chromosome is the last chromosome to start replication and also the last one to finish it.7. The semi-conservative fashion of chromosome replication and the existence of sister chromatids exchanges were detected by studying metaphases at the second division after labeling." @default.
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- W2315331603 date "1966-09-01" @default.
- W2315331603 modified "2023-10-14" @default.
- W2315331603 title "Chromosomes of the rat. II. DNA replication sequence of bone marrow chromosomes in vivo." @default.
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