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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315333367> ?p ?o ?g. }

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• W2315333367 abstract "A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostatic cell lines (DU145 and PC3). The advanced cellular evaluation of the more potent farnesyltransferase inhibitors was explored and revealed a disorganization of tubulin in PC3 cells." @default.
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• W2315333367 date "2011-02-07" @default.
• W2315333367 modified "2023-10-16" @default.
• W2315333367 title "Potent Farnesyltransferase Inhibitors with 1,4-Diazepane Scaffolds as Novel Destabilizing Microtubule Agents in Hormone-Resistant Prostate Cancer" @default.
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• W2315333367 doi "https://doi.org/10.1021/jm101067y" @default.
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