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- W2315413295 abstract "The binding of prasterone sulfate (PS) in human plasma was investigated. Binding percentages of PS to human plasma, human serum albumin (HSA), human α1-acid glycoprotein (AGP) and human γ-globulin (GGL) were independent of the PS concentration between 0.1 and 8.0 μg/ml. The mean binding percentages were 99.1% for human plasma, 98.3% for HSA, 12.6% for AGP and 8.1% for GGL. Though PS is an acidic drug, binding of PS to AGP was observed. From the binding index, it was found that PS mainly bound to HSA in human plasma and that the contributions of AGP and GGL to PS in plasma were negligible." @default.
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- W2315413295 date "1992-01-01" @default.
- W2315413295 modified "2023-09-25" @default.
- W2315413295 title "Contributions of Various Serum Proteins to the Binding of Prasterone Sulfate in Humans." @default.
- W2315413295 doi "https://doi.org/10.1248/cpb.40.2864" @default.
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